Lecture 3 - Excitable Membranes Flashcards

1
Q

What is the structure of the plasma membrane?

A

fluid mosaic model

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2
Q

What makes up the fluid mosaic model?

A

-phospholipid bilayer
-cholesterol
-transmembranal proteins

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3
Q

What is the polar section of a phospholipid?

A

polar hydrophilic head

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4
Q

What is the non-polar section of a phospholipid?

A

non-polar hydrophobic fatty acid chains (tail)

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5
Q

peripheral membrane protein
-where
-what looks like
-function

A

-inside membrane
-small not across the full membrane
-attachment + shape changes

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6
Q

integral membrane proteins
-where
-what looks like
-function

A

-across the full membrane
-channel, pump…
-transport + communication

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7
Q

cytoskeleton
-where
-what looks like
-function

A

-underneath the plasma membrane
-small, attached to other proteins
-anchors + receptors

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8
Q

carbohydrates
-specific name
-where
-what looks like
-function

A

-glycocalyx
-outside of the cell
-thin, looks like little trees
-cell-cell recognition

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9
Q

cholesterol
-where
-what looks like
-function

A

-embedded in the membrane
-it looks like a steroid structure
-stabilization

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10
Q

4 functions of the plasma membrane

A
  1. communication
  2. selective
  3. physical barrier
  4. cell recognition
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11
Q

6 functions of the plasma membrane proteins?

A
  1. enzyme activity
  2. transport
  3. receptors
  4. cell-cell recognition
  5. intracellular joining
  6. attach to ECM
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12
Q

3 types of junctions formed between cells

A
  1. desmosomes
  2. gap junctions
  3. tight junctions
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13
Q

tight junctions + where

A

-impermeable
-no random diffusion
+ blood-brain barrier

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14
Q

desmosomes + where

A

-attach
-anchor
-structure
+ cardiac muscle tissue, bladder tissue, and epithelia

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15
Q

gap junctions + where

A

-channel
-communicate
-specialize
+ all cells of solid tissue

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16
Q

how much of the brain is used to maintain the Na+/K+ ATPases pump?

A

40%

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17
Q

How is the electrochemical gradient challenged? (2)

A

1) slow leaking ions
2) stimulation of muscle

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18
Q

3 types of endocytosis

A

1) pinocytosis
2) receptor-mediated
3) phagocytosis

19
Q

what is the process of exocytosis?

A

t-snare on receptor + v-snare of vesicle attach on membrane to release outside

20
Q

what molecules can travel past the membrane by simple diffusion?

A

O2 + CO2 + fats + urea + alcohol

21
Q

state 5 features of facilitated diffusion

A

1) no ATP
2) specific
3) down conc. gradient
4) carrier saturation
5) can be inhibited

22
Q

what and where is the biosynthetic centre?

A
  • large spherical nucleus
    -glandular cytoplasms
23
Q

where is the term tract used?

A

nerve processes of the CNS

24
Q

where is the term nerve used?

A

nerve processes of the PNS

25
Q

what are the 3 special features of an axon?

A

1) extreme longevity
2) amitotic
3) high metabolic rate

26
Q

look at the drawing on the 2nd page + names 1-4 regions

A

1) receptive
2) initial segment
3) conducting
4) secretory

27
Q

receptive region of the axon
-the name of parts of the cell
-function

A

-dendrites + cell body
-receive graded potentials

28
Q

initiail segment of the axon
-name parts
-function

A

-axon hillock
-where the action potential is reached

29
Q

conducting region of the axon
-name parts
-function

A

-axon + myelin sheath
-propagate the electrical current down the axon

30
Q

2 functional divisions of PNS

A

-sensory
-motor

31
Q

how is the sensory PNS divided?

A

-somatic (skin/skeletal)
-visceral (visceral organs to the CNS)

32
Q

how is the motor PNS divided?

A

-somatic (voluntary movement of muscles)
-autonomic (self-regulated organs)

33
Q

What are the 2 principal cell types of nervous tissue and their definitions?

A

1) neuroglia
-small cells that wrap around axons

2) neurons
-excitable cells that transmit signals

34
Q

what is the 4 main neuroglia that supports the CNS neurons?

A

1) astrocytes
2) oligodendrocytes
3) microglial
4) ependymal

35
Q

astrocytes
-definition
-function

A

-highly branched that connect at capillaries and synaptic endings

-support, exchange, guide, control, respond, influence, process

36
Q

microglial cells
-definition
-functions

A

-small cells that touch and monitor neurons

-help injury + phagocytize bad stuff

37
Q

ependymal cells
-definition
-functions

A

-forms permeable membrane between the CSF and tissues

-layer the central cavities of the brain and spinal column

38
Q

oligodendrocytes
-definitions
-functions

A
  • a highly branched fatty cell that wraps around the CNS nerve fibres

-for conduction of electrical impulses

39
Q

What is the 2 major neuroglia in the PNS?

A

1) Schwann cells
-surround nerve fibres

2) ganglion
-surround neuron cell body

40
Q

What is vital to the regeneration of damaged PN fibres?

A

Schwann cells

41
Q

What do conduction velocities depend on? (2)

A

-axon diameter
-myelin sheath

42
Q

What is anterograde transport?

A

-transport away from the cell body toward the synapse
=mitos + cytoskeleton, membrane parts, nervous tissue

43
Q

what is retrograde transport?

A

-transport towards the cell body