Lecture 3 - Excitable Membranes Flashcards
What is the structure of the plasma membrane?
fluid mosaic model
What makes up the fluid mosaic model?
-phospholipid bilayer
-cholesterol
-transmembranal proteins
What is the polar section of a phospholipid?
polar hydrophilic head
What is the non-polar section of a phospholipid?
non-polar hydrophobic fatty acid chains (tail)
peripheral membrane protein
-where
-what looks like
-function
-inside membrane
-small not across the full membrane
-attachment + shape changes
integral membrane proteins
-where
-what looks like
-function
-across the full membrane
-channel, pump…
-transport + communication
cytoskeleton
-where
-what looks like
-function
-underneath the plasma membrane
-small, attached to other proteins
-anchors + receptors
carbohydrates
-specific name
-where
-what looks like
-function
-glycocalyx
-outside of the cell
-thin, looks like little trees
-cell-cell recognition
cholesterol
-where
-what looks like
-function
-embedded in the membrane
-it looks like a steroid structure
-stabilization
4 functions of the plasma membrane
- communication
- selective
- physical barrier
- cell recognition
6 functions of the plasma membrane proteins?
- enzyme activity
- transport
- receptors
- cell-cell recognition
- intracellular joining
- attach to ECM
3 types of junctions formed between cells
- desmosomes
- gap junctions
- tight junctions
tight junctions + where
-impermeable
-no random diffusion
+ blood-brain barrier
desmosomes + where
-attach
-anchor
-structure
+ cardiac muscle tissue, bladder tissue, and epithelia
gap junctions + where
-channel
-communicate
-specialize
+ all cells of solid tissue
how much of the brain is used to maintain the Na+/K+ ATPases pump?
40%
How is the electrochemical gradient challenged? (2)
1) slow leaking ions
2) stimulation of muscle