Lecture 3 Flashcards
What are the typical sugar replacements?
Sugar alcohols and polyols
How do sugar replacers get received by the body?
Sugar replacers are absorbed more slowly and metabolized differently by the body. Some are not absorbed at all and some are metabolised by colonic bacteria.
What happens if too much sugar replacers are consumed?
If too much is confused it can often cause certain side effects such as GI discomfort.
How are sugar alcohols made?
Aldehyde group is replaced by an alcohol group.
What are the typical causes of GORD?
GORD can be caused by genetics and by aging. This can be reduced by antacid use.
What is GORD?
GORD is a condition that affects the gastroesophageal sphincter which causes reflux of stomach contents to the mouth.
What is a condition that has a higher chance of occuring in people siffering from GORD?
Acid reflux can increase the risk of oesophageal cancer.
Which cells of the pancreas produce insulin?
Islets of langerhaen
What is pancreatic juice made of? Which cells secrete them?
Pancreatic juice is composed of two secretory products critical to proper digestion: digestive enzymes and bicarbonate. The enzymes are synthesized and secreted from the exocrine acinar cells, whereas bicarbonate is secreted from the epithelial cells lining small pancreatic ducts
Where does most starch digestion take place?
In the upper part of the small intestine.
What is a pharmacological application of the knowledge of the pH of different parts of the GI tract?
Pills are made to disintegrate at different pHs depending on where their products are being targeted.
Where are enzymes that break down disaccharides located in the intestines?
Enzymes that break down disaccharides are epithelial enzymes found on the epithelium of the small intestine. These enzymes are typically found as parts of enzyme complexes on the epitherlial membrane.
Where do blood vessels from the intestines go?
blood vessels from villi go through the hepatic portal vein to the liver.
How do glucose and galactose enter the cells of the intestines?
glucose and galactose enter the intestinal cells via active transport.
How do fructose and water enter the cells of the intestines?
fructose and water passively diffuse into cell via facilitated diffusion.
What does lactase deficiency cause in the intestines?
Lactase deficiency that occurs with aging or damaged villi causing the lactose to be digested by intestinal bacteria and this process causes bloating, abdominal discomfort, and diarrhoea.
How can lactose intolerance be managed?
Increase consumption of milk daily.
Mixing dairy with other foods to reduce lactose concentration.
Spreading dairy intake throughout the day.
Drinking acidophilus milk and yoghurt to aid lactose fermentation.
Use of lactase to digest lactose.
Why is lactose associated with diarrhea?
Lactose can bind to water very well and can cause soft stool (diarrhea)
What happens to lactase production with age?
It decreases with age.
What other sugars can cause intolerance with GI symptoms?
Many people are fructose intolerant. This is because fructose is absorbed slowly in the intestine compared to glucose.