Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psychophysiology - Final > Lecture 3 > Flashcards

Lecture 3 Flashcards

1
Q

Rate of Absorption & Distribution: blood circulation throughout the body

  • Entire volume of blood supply circulates every ____
A

Every minute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rate of Absorption & Distribution: blood circulation throughout the body

_____ blood pumped every minute

A

5L/min blood pumped every minute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Administration: Intravenous

A

fastest b/c it goes straight into your bloodstream

and most dangerous

30-60 seconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Administration: intraperitoneal

A

to your stomach (e.g., tubefeeding)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Administration: Subcutaneous

A

subcutaneous: into your fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Administration: intracerebral

A

intracerebral: directly into your brain; bypass the blood-brain barrier; not really done in humans but on research animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Administration: intracerebroventricular

A

intracerebroventricular: straight into CSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Administration: oral

A

oral: one of the slowest ways; first pass metabolism (broken down in saliva, down to GI tract, etc); most common way for psychotherapeutic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Administartion: Sublingual

A

sublingual: absorbing through capilaries below your tongue

*not same as oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Admin: intrarecetal

A

intrarectal: bypassess “first pass” metabolism, straight up rectum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Admin: inhalation

A

inhalation: into your lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Admin: insufflation

A

insufflation: absorbed by the mucous membrane in your nose (e.g.,
snorting cocaine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Admin: topical

A

Topical: on your skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how long does intravenous take

A

30-60 seconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Oral vs IM vs IV: blood concentration and time

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where do drugs exert their effects

A

Sites of action

17
Q

Distribution: Entry of Drugs into the Brain –> where bind

A
  • Drugs exert effects only at their sites of action
  • Mostly on or in cells of the CNS
18
Q

Distribution: Entry of Drugs into the Brain

What is the most important factor in determining the rate of distribution

A

Most important factor in determining the rate is lipid solubility

  • Recall the BBB –> Lipid soluble materials pass through most rapidly
  • Heroin > Morphine (heroin has higher level of lipid solubility, so it has a faster effects, so its more addictive)
19
Q

What passes throgh the BBB

A

Lipid soluble

Water

Specialized sugars

check

20
Q

Therapeutic Index

A

Commonly used margin of safety

Look at ratio between ED50 and TD50

Effective Dose 50 (ED50) = the dose that produces the desired effects in 50 percent of the individuals

Toxic Dose 50 (TD50) = the dose that produces toxic effects in 50 percent of the individuals

21
Q

Therapeutic Index Desired Ratio

A

TI= TD50/ED50

WANT IT BIGGER THAN 10
(want toxic dose to be a lot bigger than effective dose)

Lower ratio is more dangerous (smaller margin of safety)

22
Q

Most drugs affecting behavior affect…

A

Synaptic transmission (antagonist or agonist)

23
Q

Agonist

A

Agonist a molecule that by binding to the receptor stimulates a
response = ↑ postsynaptic effects

24
Q

Antagonists

A

Antagonists a molecule that by binding to a receptor blocks or
inhibits the response = ↓ postsynaptic effects

25
Q

Addictive drugs more often agonist or antagonist

A

Agonist!

Addictive drugs (heroin, morphine, oxycodone) –> stimulation leads to “high”

26
Q

Is botox an agonist or antagonist

A

antagonist!

Botulin poison causes paralysis by blocking release of acetylcholin.
wrinkles cannot form d/t the area being paralyzed

27
Q

Antagonsit vs agonist

A
28
Q

Agonist or Antagonist?

A drug that blocks the re-uptake or enzymatic degradation of a neurotransmitter?

A

Agonist

Your channels on neuron one are blocked, so you have a bunch of your transmitter in the cleft, and neuron 2 keeps firing. Since increasing firing in neuron 2, agonist

29
Q

If the activation of a receptor causes vasoconstriction, what would
happen if someone took an antagonist for that receptor?

A

Decreases vasoconstriction

Psychophysiology - Final (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions