Lecture 25 Flashcards
genome
ssRNA (+) sense
how can we detect covid
RT PCR
fusion process
spike uses TMPRSS2 protease to cleave spike then the virus enters the cell when the spike fuses to ACE2 `
viral vector vaccine
use adenovirus
mrna vaccine
spike protein in lipid nanoparticle
s2p
prefusion spike
vaccine with s2p
makes antibodies to destory the spike pre fusion
what do covid variants mutate
spike protein and becomes convergent evolution if it fuses better than the original
how does omicron escape neutralization from antibodies
its spike doesn’t need TMPRSS2
how can affinity help fight against different strains
hypermutations/ affintiy could maybe make an antibody that fights the strains well
non neutralizing antibodies
clump the virus for aggregation or precipitate for phagocyte
vaccine stimulate
a t cell response independant to neutralization just less instantaneous
