Lecture 19

Question 1

variable penetrance

Answer 1

some have it and some dont

Question 2

if genetically identical what would play a role in the variable

Answer 2

the environment
-ex: brca mutation risk changed with lifestyle

Question 3

conditional allele

Answer 3

allele depends on the environment
heat rabbit, drosophilia paralysis, auxotroph, pku

Question 4

waddington

Answer 4

marble has noise and there are bumbs that change phenotype
-methylation and histonesis

Question 5

prader willie

Answer 5

paternal delete

Question 6

is mosaic post germline

Answer 6

yes

Question 7

where does variability start

Answer 7

TF
ex: can change when exposed to IPTG

Question 8

HSP90

Answer 8

-helps proteins fold into the right shape
-increase temp increase hsp 90 to prevent aggregation and keep shape from heat

Question 9

complex quantitative

Answer 9

high environment component (height hair etc)

Question 10

non mendelian factors

Answer 10

penetrance, environment, epitasis, supressors, synthetic alleles, genetic buffer etc

Question 11

what you inherit

Answer 11

mean + variability

Question 12

H=1

Answer 12

variation from inheritance

Question 13

H=0

Answer 13

environment/ random