Lecture 24: Evidence Literacy

Question 1

5 main types of foreground clinical qs

Answer 1

Therapy: Determining the effect of interventions on patient important outcomes

Harm: Ascertaining the effects of potentially harmful agents on patient important outcomes

Differential Diagnosis: In patients with a particular clinical presentation, establishing the frequency of the particular disorder

Diagnosis: Establishing the power of a test to differentiate those with and without a target condition or disease

Prognosis: Estimating a patient’s future course if we do nothing

Question 2

Disease oriented evidence (DOE)

Answer 2

Studies that address factors such as organ function or biochemical levels in the blood. (i.e., surrogate outcomes)

Question 3

Patient Oriented Evidence (POE)

Answer 3

Information, based on good science, that tells clinicians that what they do
helps patients live longer and/or better lives (i.e., patient important outcomes)

Question 4

How to tell the difference?

Answer 4

– Ask yourself: “Can a patient feel the outcome?”
– If the answer is “No” then it is a surrogate marker

eg. lower bp infers lower mortality

Question 5

see table for exercise

Answer 5

ok