Lecture 23C - Skin Infections Flashcards

1
Q

What is the cause of acne vulgaris?

A

blockage of the psilosebaceous unit by propionium bacterium acnes can allow infection and formation of pustules

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2
Q

What are the symptoms of acne?

A

if the infection is severe and the hair follicle ruptures, scarring can ensue

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3
Q

What does colonisation of the blocked psilosebaceous unit cause?

A

formation of whiteheads, blackheads and pustules

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4
Q

Treatment of acne vulgaris?

A

depending on severity

topical benzoyl preoxide

tetracycline might be considered if symptoms are severe

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5
Q

What are the two most common bacteria causing skin infection?

A

staphylococcus aureus and streptococcus pyogenes

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6
Q

What are vesicles?

A

smaller fluid filled blisters the size of a pin head (<0.5m in diameter)

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7
Q

What are bullae?

A

larger fluid filled blister-like eruptions around 1cm (>0.5cm)

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8
Q

What is impetigo?

A

bacterial infection in the skin which commonly affects face or extremities following injury

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9
Q

What can form with impetigo?

A

bullae and/or vesicles can form, very contagious

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10
Q

Causative factors of impetigo?

A

usually caused by S aureus and S pyogenes

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11
Q

Symptoms of impetigo?

A

non-bullous type has pinhead pustules on red skin which erupt to give yellow-brown crust after skin injury (around 70% of cases)

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12
Q

Bullous type of impetigo?

A

has larger blisters which release a clear yellow liquid to leave a golden yellow crust (usually S aureus on intact skin)

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13
Q

Treatment of impetigo?

A

topical treatment with bacitracin or mupirocin
although resistance in some areas

care in playgroups to avoid spreading

often resolves spontaneously

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14
Q

What causes ecthyma?

A

often progresses from untreated impetigo

poor hygiene, poor ventilation of skin, insect bites, immunocompromised conditions

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15
Q

What is ecthyma commonly associated with?

A

S pyogenes and S aureus, however other bacterial species can be associated

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16
Q

Signs of ecthyma?

A

infection penetrates to deeper layers of the skin causing the appearance of painful ulcers

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17
Q

Treatment of ecthyma?

A

warm compress and antibiotics e.g. dicloxacillin

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18
Q

Folliculitis causes?

A

infection of hair follicles by S aureus

often affects beards, armpits and back of the neck

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19
Q

Symptoms of folliculitis?

A

red pustules (furuncles) form and eventually rupture in a few days

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20
Q

Treatment of folliculitis?

A

should be self limiting

topical clindamycin and erythromycin on affected areas if necessary and antibacterial soap

larger abscesses (carbuncles) may need to be surgically drained

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21
Q

Causes of erysipelas?

A

involved lymphatic vessels

often caused by S pyogenes and cellulitis by S aureus (inc. MRSA)

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22
Q

What can erysipelas cause?

A

systemic illness if untreated by passing through lymphatic vessels

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23
Q

Signs and symptoms of erysipelas and cellulitis?

A

pain ful, warm, red swelling which forms a well defined plaque

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24
Q

Treatment of erysipelas?

A

penicillin

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25
Q

Treatment of cellulitis?

A

dicloxacillin

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26
Q

What is erysipelas also known as?

A

St Anthony’s fire due to red borders round infection

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27
Q

What happens in cellulitis?

A

the infection has penetrated into subcutaneous tissue

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28
Q

Borders of cellulitis infection?

A

not well defined, much less than erysipelas

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29
Q

What can cellulitis lead to?

A

sepsis, requires antibiotic treatment and consideration of hospital admission

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30
Q

What is necrotizing fasciitis?

A

infection of subcutaneous tissue which can occur after surgery or trauma

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31
Q

What is necrotizing fasciitis caused by?

A

S pyogenes alone but often involves a mixture of bacteria

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32
Q

Symptoms of necrotizing fasciitis?

A

starts with war red skin but lesion rapidly expands vertically and horizontally

tissue becomes dark, pustular then necrotic *blackened areas where tissue as died) with gengrene

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33
Q

Treatment of nectrozing fasciitis?

A

fatal without prompt treatment

surgical intervention required along with parenteral antibiotics such as gentamicin and clindamycin

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34
Q

What happens if the infection becomes gangrenous?

A

no option other than to remove the leg

35
Q

Why do physicians mark out infections sometimes?

A

to make sure it is not progresing

36
Q

What is lupus vulgaris?

A

brown nodules on the face caused by mycobacterium tuberculosis

37
Q

Lugus valgaris treatment?

A

requires susceptible antibiotic drug combinations

38
Q

Leprosy?

A

caused by mycobacterium leprae and lepromatosis

39
Q

Symptoms of leprosy?

A

brown nodules, white patches on skin and neuropathy

40
Q

Treatment of leprosy?

A

requires long term antibiotic treatment

41
Q

What is the most common infectious fungus?

A

trychophyton rubrum

42
Q

What do most fungal infections involve?

A

trichyphyton, microsporum and epidermophyton

43
Q

What are the forms of tinea?

A

tinea pedis

tinea cruris

tinea capitis

tinea corporis

tine unguium (onychomycosis)

44
Q

What does tinea pedis cause>

A

athlete’s foot

45
Q

What does tinea cruris cause?

A

jock itch in the groin

46
Q

What does tinea capitis cause?

A

cradle cap in babies - white coating on the skull of babies

47
Q

What does tinea corporis cause?

A

ringworm on the trunk

48
Q

What does tinea unguium cause?

A

infection of nails (60% of people over 80)

49
Q

Treatment of tinea?

A

terbinafine, clotrimazole or econazole

50
Q

What are cutaneous fungal infections given the name?

A

tinea or ringworm

51
Q

How many adults suffer from tinea pedis?

A

70%

split skin can cause opportunity for secondary bacterial superinfections to take place

52
Q

What might be preferred treatment for some types of tinea?

A

systemic antifungals

53
Q

What is tinea versicolor?

A

caused by the widespread yeast malassezia furfur, more common in hot climates

infection of malassezia furfur in the outer layer of the epidermis

54
Q

Symptoms of tinea versicolor?

A

results in lightened or darkened pigmentation in patches of the skin in upper body and limbs

55
Q

Treatment of tinea versicolor?

A

zinc or selenium sulfide shampoo or topical antifungal agents

56
Q

How long can it take for normal pigmentation to return?

A

6 weeks and in this time there can be patches of discoloured skin

57
Q

What is candidiasis caused by?

A

the yeast candida albicans, a normal member of the gut flora and genitourinary tract in humans

58
Q

Symptoms of candidiasis?

A

inflamed and itchy membranes in moist mucous tissues such as mouth, vagina, armpits etc

59
Q

What can candidiasis of the mouth be associated with?

A

an immunocompromised condition or the use of dentures which have not been disinfected properly

60
Q

Treatment of candidiasis?

A

topical antifungals, plus possibility of systemic antifungals such as ketaconazole, fluconazole

61
Q

Herpes simples (1) and cold sores?

A

85% of the population have antibodies to HSV type 1

virus residues in the dorsal ganglia, until reactivated

62
Q

Symptoms of HSV 1?

A

self limiting eruption around mucous membranes of the mouth

63
Q

Treatment of HSV1?

A

aciclovir in a cold cream formulation

but cold sores are usually self limiting

64
Q

Varicella zoster virus?

A

chicken pox and shingles

during chicken pox, virus travels to sensory ganglia where it remains for life

65
Q

Symptoms of varicella virus?

A

pain and paresthesia in an affected dermatome

66
Q

How does the varicella virus erupt in later years?

A

in the band of skin (dermatome) supplied by the nerve ganglion which is harbouring the virus

67
Q

What can shingles cause?

A

pain and a sensation of tingling, itching, numbness or burning in the affected areas

68
Q

Treatment of varicella zoster virus?

A

usually resolves with rest and analgesia, but aciclovir can be used, especially if virus is disseminated

69
Q

What causes warts?

A

the human papilloma virus (HPV)

70
Q

What are warts?

A

benign skin tumours caused by infection with the human papilloma virus (HPV

71
Q

Appearance of warts?

A

dark necrotised blood vessels at the heart of the ward

72
Q

Common (plane) wart?

A

(verucca vulgaris)

affects the hands and face and knees and can spread

73
Q

Plantar wart?

A

verucca plantaris

grows into the skin of the sole of the foot and can cause pain

74
Q

Treatment of warts?

A

will often resolve spontaneously but can be removed by some form of chemical (salicylic acid), cry or surgical ablation

75
Q

What can some strains of warts increase?

A

the risk of cervical cancer, but there is not a vaccine against this (Gardasil)

76
Q

Treatment of warts in children?

A

waiting to see if they go away

77
Q

Molluscum contagiosum?

A

a pox virus transmitted by direct skin contact

78
Q

Symptoms of M contagiosum?

A

hyperplasia

raised pink, pearl like, pus filled lesions with a central depression

79
Q

Treatment of M contagiosum?

A

often resolves spontaneously but can linger in immunocompromised patients (for months or sometimes yeasrs)

80
Q

Treatment of M contagiosum in children?

A

treated conservatively, but broadly similar as for warts with addition of curettage and cantharidin

81
Q

What is a curettage?

A

scooping out the virus and papule with a very tine spoon

82
Q

What is cantharidine?

A

comes from beetles and is a blister agent

83
Q

How can M contagiosum be transmitted?

A

skin contact but can also be sexually transmitted

84
Q

Common parasitic infections?

A

scabies and head lice