Lecture 23: Helicobacter Pylori Flashcards
Recall the correlation between microbiota and disease
Pathogenicity is determined by:
Recall normal stomach morphology.
Recall what makes the stomach a hostile/sterile environment.
Recall some of the diseases in the GIT.
Describe chronic gastritis.
Describe gastrically adenocarcinoma
Describe gastric lymphoma.
Describe peptic ulcer.
Recall early treatment to gastric ulcers.
Briefly recall GIT microbial diversity.
Describe H. pylori.
Recall the factors behind H. pylori survival in the stomach.
Recall the relationship between H. pylori and GIT diseases.
Recall the other causes of peptic ulcer.
Recall epidemiology of H. pylori infection.
What factors affect H. pylori pathogenesis.
Recall the factor behind H. pylori genetic diversity.
Describe the factors behind H. pylori virulence.
Recall the host response to H. pylori infection.
- All H. pylori strains induce a marked immune response
- Expression of pro-inflammatory cytokines and chemokines from gastric epithelial cells
- Infiltration of immune cells
- Production of ROS and RNS
- Binding to gastric epithelium - BabA
- Damage to gastric epithelium-CagAand VacA
- Acute inflammatory response neutrophils and macrophages
- Chronic inflammatory response involving the recruitment of T-cells (Th1-mediated response)
Binding of H. pylori to epithelial cells initiates an __________________, which becomes _________ with the development of an adaptive immune response.
Binding of H. pylori to epithelial cells initiates an acute inflammatory response, which becomes chronic with the development of an adaptive immune response.
Recall H. pylori immune evasion.
Recall the specific immune response and pathogenesis and H. pylori.
Recall the consequences of severe gastritis.
Describe gastric and duodenal ulcers caused by H. pylori infection.
Recall the consequences of H. pylori infection.
Recall the treatment and prevention of H. pylori infection.
