Lecture 18: Cancer Genetics Flashcards
Recall the hallmarks of cancer
Recall the concept of molecular profiling to classify tumours.
How do we assess gene expression effects?
The Kaplan–Meier estimator, also known as the product-limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data. In medical research, it is often used to measure the fraction of patients living for a certain amount of time after treatment.
Recall examples of inherited forms of cancers.
Predisposition for developing cancer is often the result of being ________________________. Recall the concept of LOH.
Recall molecular tests to detect TSG defects
Tumours are classified by ____________.
Ovarian tumours originate from __________.
Recall the different histology, precursors, and distinctive molecular of “ovarian cancer”.
Recall the molecular pathways to cancer.
Recall TSG and oncogenes
An oncogene is a gene that has the potential to cause cancer.
A tumor suppressor gene, or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1] If the cell grows uncontrollably, it will result in cancer.
How does immune checkpoint inhibitors work?
Recall examples of therapeutic approaches to intervene in tumour-stroma dialogue.
Recall the problem with colorectal cancer.
Recall common TSG defects predispose to cancer development
Recall other factors that affect tumour progression.
