Lecture 17: Epigenetics

Question 1

Define epigenetics.

Answer 1

Epigenetics is the study of changes in heritable phenotype and gene expression that do not involve alterations in the DNA sequence.

Question 2

Define epigenomics.

Answer 2

The study of the complete set of epigenetic modifications on the genetic material of a cell

Question 3

What is epigenomics medicine?

Answer 3

Epigenetic targets in disease that can be modified by pharmacological intervention.

Question 4

What is non-coding DNA?

Answer 4

Originally referred as “junk” DNA. Mostly regulatory sequences - encode critical biochemical functions.

Question 5

Recall the impact of epigenetics on agouti gene.

Answer 5

Question 6

Describe nucleosome.

Answer 6

Question 7

Epigenetic regulation is important for ______________, ___________, and _______

Answer 7

DNA metabolism transcription, and repair

Question 8

Differ between heterochromatin and euchromatin.

Answer 8

Question 9

Recall examples of histone markers and the activities associated with it.

Answer 9

Question 10

Recall the concept of DNA methylation.

Answer 10

Genomic DNA may be methylated at the 5th position of cytosine, typically in the sequence of CpG; known as CpG islands.

Question 11

Recall the impact and prevalence of DNA methylation in cancer.

Answer 11

Question 12

Recall the effect pf DNMT inhibitors as anti-cancer agents

Answer 12

Question 13

Recall the types of histone modifications

Answer 13

Question 14

Histone acetylation is regulated by _________ and ______________.

Answer 14

Question 15

Recall examples of HDAC inhibitors.

Answer 15