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Darrens class Midterm > Lecture 22-25 > Flashcards

Lecture 22-25 Flashcards

1
Q

How do antagonists affect neurotransmission? (One each for five steps) (blocks,promotes)

A

Blocks/reduces synthesis of NT
blocks reduces storage in vesicles
Blocks reduces/release of NT
block or reduce activation of NT receptors
promote re uptake NT breakdown

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2
Q

How do agonists affect neurotransmission?( enhance,promote,activate,block reduce)

A

enhance synthesis of NT
enhance storage in vesicle
promote or directly cause NT to release
activate NT receptors or enhance sensitivity
Blocks/reduce NT re uptake

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3
Q

why do some people have more side effects then others? due to four things (NS,metabo,circ,interact)

A

All our nervous system are different

all metabolize drugs differently

circulation
how drug interacts with body

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4
Q

What are drug effects?

A

Drugs produce effects we do/don’t want

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5
Q

What are the three complications of drugs? (affect more,psych effects determined..,nature of..)

A

many drugs Affects more than one type of NT

psychological effects are determined by how drug affects info processing in brain circuits

How drug alters circuit depends upon nature of it

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6
Q

what are the two drugs that effect neurotransmission in more than one way and how? (e,c)

A

ecstasy-effects vesicular storage and reuptake for serotonin

cocaine-inhibits dopamine re uptake transporter and activates dopamine receptor

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7
Q

What do drug effects relate to? (where in..,functions of

A

drugs effects relate to where drug is distributed in brain and functions of NT/receptor

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8
Q

What are side effects? and how are they produced

A

changes we don’t want produced by drugs effect on synapses

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9
Q

what’s the ideal drug? 3 things should be effected (only1.., particular b..vary) Produce..

A

produce desired effect in brain and circuits
Affects only 1 NT/receptor
affects particular brain area
effects aren’t varied (1 thing)

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10
Q

What are recreational drugs?

A

meds we take cause we like them not because we need them

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11
Q

What effects do drugs produce and what two mechanisms mediate drug effects? (psy,phys) (psyc..s and c)

A

drugs produce psychological physiological effects

Mechanisms that mediate drugs: psychoactive synapses and circuits

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12
Q

what’s the prevalence of rec. drugs?

A

1/20 people misuse drugs on regular basis in USA

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13
Q

relationship between dosage and effect of drug? and what are the routes of administration?

A

Route of administration matters, most effective inhalation

Other routes: oral,injection,trans nasal,trans dermal

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14
Q

Where was nicotine found how long did it take to spread globally and routes of administration for it? (3 routes)

A

South america took less than 400 years to spread globally
Routes of administration: Inhalent,trans dermal,trans mucusol

very lipid soluble, get nic sick from sticking butt in a bucket of nicotine

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15
Q

What are the four psychological effects of nicotine? (increase a,suppress,enhance cog..,stimulates…)

A

Increases arousal
enhance cognitive ability’s
stimulates nausea
suppress appetite

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16
Q

what are the 2 physiological effects of nicotine? (increased..,reduced..)

A

Increased heart rate and blood pressure

reduced muscle tone- relaxed feeling of smoking

17
Q

Nicotine mechanism of actions (2 steps) and what is nicotines NT receptor and receptor and is it agonist or antagonist?

A

NT Receptor is acetylcholine, is agonist. RECEPTOR: cholinergic receptor

  1. Acetylcholine produces effects by activating cholinergic receptors in post synaptic neurons
  2. Nicotine then acts by activating certain cholinergic receptor
18
Q

How’s ethyl alcohal produced? (yeast having a feast)(can be con..)

A

produced by fermentation of edible sugars and can be concentrated through distillation

19
Q

How to find dose of alcohal taken? (volume,%)

A

volume drank times the percentage of alcohal =dose taken of alc.

20
Q

3 steps to alcohols clearance and how does it take to clear alcohol?
(IMD)

A

INPUT- drinking alcohal
metabolized by alcohal dehydrogenase enzyme
Alcohol dehydrogenase enzyme destroys alcohol molecule
up to 24 hrs

21
Q

Enzymes are inducable what’s that mean? Depends upon 2 things (t.L,B.M)

A

How much your body makes of enzyme depends upon, varys highly
1. tolerance levels
2. body mass

22
Q

how much alcohol effects you depends on two things:
d,a

A

dosage
absorption of body

23
Q

Alcohol is eliminated passively through?
(KLSS)

A

Kidneys
lungs-breath out alchohol
molecule
stinken drunken-smell drunk
skin-secretes alcohol molecule through pores

24
Q

What are BAL and the equation for
a male?

A

blood alcohol
levels, alcohol (mg) divided by 100 ml blood

equation for adult male : approx number of drinks (ml) - time consumed(hrs) *0.015

25
Q

What’s the driving alcohol
limit and the limit to lose your license?

A

0.5 for driving
0.8 to lose your license

26
Q

What are the 7 alcohol levels of performance and what do they mean? (M,may..,L,G,S,C,D)

A

Below 0.4- mild intoxication- no effect
0.4- may be viewed as intoxicated but barely
0.8- legal intoxication, some visibly drunk
0.16-gross intoxication- interpersonal could see they’re drunk
0.28- stupor-responsive,semi conscious
0.32- coma- unresponsive, im onions
0.048-0.5- death- lethal dose of alc, Nervous system shuts down

27
Q

What’s inhibitory control?
(f U or thank U)

A

Controls impulses and can be very impactful. Saying f u to service worker who gives you your grocery’s instead of thank you

28
Q

What are the 4 psychological effects of alcohol? (Brain,Im,Im,Im) What does the level of impairment depend on too?

A

Brain depressant-inhibitory to all functions
Impaired cognitive function
impaired motor function
impaired sensory function
impaired inhibitory control

Level of impairment depends on dosage

29
Q

What are the three physiological effects of alcohol? (so much pee,lots of snacks!,metabolize what peopel like most is reduced)

A
  1. Pee region is inhibited (antiuretic)and secretion is produced much more (need to pee more)
  2. increased appetite, gastric secretion
  3. inhibits fat metabolism: less ability to metabolize fats when alcohol in system
30
Q

Mechanism of action for alcohol (THE TWO G’s) and what happens when alcohol enter system (promote,inhibit) (first G: ups,two steps; second G: 3 steps, increase decrease, downs.neuron)

A

cells work poorly, has two NT effects on GABA AND GLUTAMATE

  1. GABA Agonist increases activity in synapse, by binding to GABA receptors and enhancing NT (upping activity) to create stronger reaction
  2. GLUTAMATE.antagonist inhibits neuronal activity
  3. disrupts cell membrane
  4. increase in GABA NT
  5. decrease GLUTAMATE NT
31
Q

Why does GABA and gluatamate have such broad effects?

A

as they’re found in all different regions and alcohol disrupts eveything

32
Q

Where was marajuana first derived from and first recreationally used? Also what happened in 1920?

A

India was derived from

first used recreationally in caribbean

prohibition of alcohols in 1920, weed got popular instead

33
Q

what are the benefits (3) and routes of administration of marajuana? (2)

A

benefits
1. increase appetite
2. suppress pain,nausea
3. reduce anxiety

routes of administration
1. inhalent-bong (most effective)
2. orals: edibles-oils

34
Q

Psychological effects of marajuana? ( RAIIE)

A
  1. reduced anxiety and pain perception
  2. amotivational syndrome: weed smokers less motivated than those who don’t
  3. increase appetite
  4. Impairment: short term memory, perception, motor coordination
  5. Euphoria
35
Q

Physiological effects of MJ? (5) (RIRRI)(reduced)

A
  1. Reduced want for sex aggression
  2. increased libido
  3. respiratory effects: damage bronchodilation
  4. reproductive system effects: reduced fertility in F AND M
    5, Increased heart rate and dilated blood vessels
36
Q

what’s bronchodilation and damage ?

A

bronchodilation is relaxing of throat

damage: is hot air from smoking causing damage to lung tissue

37
Q

MJ can play as what in some disorders?

A

Mj marajuana can play as a tipping point in some recurring disorders like schizophrenia

38
Q

what are the two main Marajuana molecules and mechanism of action (2 steps) (Canna. r,Ana. NT binds) effects whole

A

two main molecules in marajuana: CBD ,THC

mechanism of action
1. Cannabinoid receptors bind to Anandamine NT and 2 molecules bind to receptor
2. MJ affects whole brain, binds widespread

Darrens class Midterm (10 decks)

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