Lecture 22 Flashcards

1
Q

What is the first law of thermodynamics?

A

The total energy within a system is constant, energy cannot be created or destroyed, only converted between forms

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2
Q

What does biology and biochemistry rely on?

A

Energy conversions

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3
Q

Where does energy in biology originate from?

A

The sun - light energy

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4
Q

How does photosynthesis convert energy to useful forms?

A

Absorbs the light energy, with an additional intake of CO2 and generates ATP and O2

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5
Q

What is the ATP generated in photosynthesis used for?

A

Anabolism

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6
Q

What is anabolism?

A

Using energy to make bigger molecules (fuel molecules)

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7
Q

What is the energy generated through eating used in?

A

Catabolism

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8
Q

What is catabolism?

A

Generating ATP from breaking chemical bonds

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9
Q

What is the ATP generated in catabolism used for?

A

Cellular work e.g. anabolism, transportation or signalling

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10
Q

What is ATP

A

Adenosine triphosphate

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11
Q

Where is the energy stored in ATP?

A

In the phosphoanhydride bonds (P-O)

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12
Q

What is ATP synthesis

A

How ATP is synthesised from ADP + P using the energy generated from the catabolism of dietary fuel molecules

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13
Q

What is ATP hydrolysis?

A

How ATP is used on anabolic precursors to generate products of cellular work

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14
Q

What is hydrolysis?

A

Reaction where a chemical bond is broken using water, the water molecule is then consumed in the separation of a larger molecule

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15
Q

What is macronurtients?

A

Large molecules, polymers, consumed in food

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16
Q

What are the macronutrient polymers?

A

Carbohydrates, protein, fat, nucleic acids

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17
Q

What is the monomer of a carbohydrate?

A

Monosaccharides (glucose)

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18
Q

What is the monomer of a protein?

A

Amino acids

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19
Q

What is the monomer of fat?

A

Fatty acids

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20
Q

What is the monomer of nucleic acids?

A

Nucleotides

21
Q

What does digestion involve?

A

hydrolysis of bonds connecting monomer units and absorption from GI tract into body

22
Q

After the consumed polymers are catabolised, what are the monomers used for?

A

Anabolism to create functional gene polymers

23
Q

What is micronutrients?

A

Minerals and vitamins consumed in the diet, and used as cofactors

24
Q

What are minerals?

A

Inorganic elements consumed in the diet

25
Q

What are the two types of minerals?

A

Major and minor

26
Q

What are the major minerals?

A

Inorganic elements with a great abundance in the body

27
Q

What are the minor minerals?

A

Inorganic elements with a low abundance in the body therefore at low concentrations so can be hard to identify and measure

28
Q

What are vitamins?

A

Organic substances in the diet

29
Q

What are the two types of vitamin?

A

Water soluble and fat soluble

30
Q

What are water soluble vitamins?

A

Vitamins that cannot be stored, B class in metabolism

31
Q

What are the fat soluble vitamins?

A

Vitamins that can be stored in the adipose fat and mobilised when needed

32
Q

What is a cofactor?

A

Small molecules required for the activity of an associated enzyme. They have a range of mechanisms

33
Q

What are coenzymes?

A

A type of cofactor, organic and often derived from vitamins

34
Q

What are the key features of coenzymes in pathways?

A

Low concentration in cells, can act as carriers and have two forms

35
Q

What are the key coenzymes?

A

NAD, FAD, CoA

36
Q

What is gibbs free energy?

A

A measure of the spontaneity of a reaction

37
Q

If ΔG < 0 for A → B then?

A

The reaction is spontaneous, energy is released as A > B and the reaction is energetically favourable

38
Q

If ΔG = 0 for A → B then?

A

The reaction is in equilibrium, there is similar energy is A and B and no work can be done; no driving force

39
Q

If ΔG > 0 for A → B then?

A

The reaction is non-spontaneous, energy is required as B > A and the reaction is energetically unfavourable. An enzyme cannot make this happen

40
Q

Is ATP hydrolysis energetically favourable or unfavourable?

A

Favourable, ΔG = -30kJ/mol

41
Q

Is ATP synthesis energetically favourable or unfavourable?

A

Unfavourable, ΔG = 30kJ/mol

42
Q

What are the two key pathways of reaction types?

A

Those involving ADP → ATP
and RedOx reactions

43
Q

What occurs during redox reactions?

A

Fuel molecules get oxidised

44
Q

What is oxidation?

A

The loss of an electron, this is the reducing agent and provides reducing power

45
Q

What is reduction?

A

The gain of an electron, this is the oxidising agent and provides oxidising power

46
Q

What do biological redox reaction often use?

A

A hydrogen atom, therefore referred to as a reducing equivalent

47
Q

What is the name for the enzymes that catalyse redox reaction using a H atom?

A

Dehydrogenase

48
Q

What is the stepwise oxidation pathway?

A

The process of capturing energy from sugar through breaking the bonds using a series of steps instead of just one

49
Q

Why do we need the stepwise oxidation pathway?

A

Because directly burning sugar releases all the energy as heat which is not useful in the cell