Lecture 21 - neurodegeneration

Question 1

Replacement of dopamine

Answer 1

L-dopa

Question 2

Reduced metabolism of dopamine

Answer 2

Selegiline - selective MAOAb inhibitor

Question 3

Direct dopamine agonist

Answer 3

Bromocriptine, apomorphine

Question 4

Release dopamine

Answer 4

Amantadine

Question 5

Block cholinergic effects

Answer 5

Benztropine, benzhexol

Question 6

Peripherally-acting DOPA decarboxylase inhibitor

Answer 6

Carbidopa and benserazide

Question 7

What are the acute side effects of L-dopa

Answer 7

Nausea - treat with domperidone (dopamine antagonist) Hypotension Psychoses

Question 8

Use of COMT inhibitors

Answer 8

Entacapone / Tolcapone

Question 9

Ergot alkaloid

Answer 9

Bromocriptine and pergolide

Question 10

What drugs are used for selective D2 receptors?

Answer 10

Pramipexole and ropinirole

Question 11

Dopamine agonist has to control “off effect” with L-dopamine

Answer 11

Apomorphine

Question 12

Amantadine

Answer 12

Increase dopamine release Inhibit amine uptake Directly acting on dopamine receptors

Question 13

Brain: MAO-B

Answer 13

Selegiline and Rasagiline

Question 14

Brain: COMT

Answer 14

Tolcapone

Question 15

Brain: D1 and D2 receptors

Answer 15

Pramipexole Ropinirole Rotigotine Bromocriptine Apomorphine

Question 16

Periphery: DDC

Answer 16

Carbidopa and Benserazide

Question 17

Periphery: COMT

Answer 17

Entacapone and Tolcapone