Lecture 21 Flashcards
Transmission through AV node is ______ due to smaller fibers and fewer gap junctions
Slower
True or false? Delay through AV node allows atria to contract before the ventricles contract.
True
Bundle of His conducts the action potential very fast or very slow?
Very Fast
Bundle of His is also know as what?
AV bundle
This is the natural pacemaker of the heart
SA Node
True or false? The SA node has contractile proteins
False
True or false? The SA node specialized muscle tissue
True
Fibers of SA node connect directly to what?
Regular myocardial fibers of atria
Action potential that is generated in SA node fibers travels immediately to atrial fibers and causes what to happen?
Atrial depolarization
The fibers of the SA node fire action potentials in rhythmic pattern of about 100 bpm via what mechanism?
Self-excitation
True or false? The fibers of the SA node are not permeable to Na+
False - the SA node fibers allow Na+ to leak in
True or false? Resting membrane potential of SA node is less negative in comparison to other fibers
True - resting membrane potential in SA node is -55 mV compared to -90 in other fibers.
- Depolarization up to threshold- mostly due to slow Na+ influx
- Rapid depolarization- opening of L(“longlasting”)-type Ca++ channels
- Repolarization- opening of K+ channels
Action potential of autoarythmic cell
Heart rate is set by the __ _______
SA node
_____ increases heart rate and contractility
SNS
_____ decreases heart rate and contractility
PNS
SNS releases what NT?
Norepinephrine
In SA node, Norepi _______ Na+ permeability, which increases restimg membrane potential, and increases rate of drift towards threshold
increases
In cardiac myocytes, Norepi _______ intracellular Ca++ concentration which _______ contractility
Increases, increases
Vagus nerve releases what NT?
acetylcholine
Acetylcholine release from Vagus nerve causes what?
Increase in permeability to K+, causing hyperpolarization
Hyperpolarization causes _____ rate of SA node firing and ______ excitability of AV jucntional fibers
Decreased, decreased