Lecture 20 : Latency and Activation Flashcards
1
Q
Note
A
Some proteins are synthesised as inactive species, need to be activated by proteases
2
Q
Signal hypothesis
A
3
Q
What are pro-peptides for
A
4
Q
Secretory vesicle pathways
A
5
Q
What is pro-peptide cleavage
A
- Essential for activation
- Cleavage site contain residues that are removed after cleavage by carboxypeptidase
6
Q
What are PCSKs
A
- Proprotein Convertases Substilisin / Kexin
- Enzymes that cleave proteins at specific sites
- Cleave mostly C terminal to argenine
unfinished - Allow for mature protein production, correct expression of proteins
7
Q
Role PCSKs in insulin maturation
A
- Insulin synthesised as pre-pro-insulin
- Pre- part is cleaved
- Generates pro-insulin (inactive)
- Then folded correctly and processed by other PCSKs and then it is secreted as mature insulin in vesicles
8
Q
What are matrix metalloproteinases (MMPs)
A
Act on ECM
- Wound healing
- Tissue remodeling
- Immunity, inflammation
- Ovulation
- Pregnancy
9
Q
What are secretases
A
Activate surface proteins idk
