Lecture 2: Ss system- DCML Flashcards
what is a macroscopically
structures that detect stimuli
what is a microscopically
molecules interacting with the stimuli
what is the breakdown for a receptor
directly detecting a stimuli, rich in mitochondria
1. cell so a neuron (olfactory receptor neuron) or non-neuron ccell (hair, rods/cones, merkel)
2. nerve ending so specialized capsules or free nerve ending
what does a mechanoreceptor detect
touch
vibration
stretch
what does a chemoreceptor detect
taste
smell
pH
O2
what does a thrmoreceptor detect
cold to hot
flavor of food
what does a nociceptor detect
noxious stimuli
what is the function of free nerve endings
functions of all receptors
differentiated through electric stimulation
what is special sensory receptors
electromagnetic waves such as rods/cones
how is conscious localization maintained
projecting to S1 to maintain somatotopy
how is unconscious localization maintained
projecting to subcortical structures
RF or cerebellum
how do the receptors encode duration of the stimuli
receptor graded potential is what measures duration. when the stimuli stops so does the receptor graded potential. however, it can have lagging effects
how do the receptor graded potential encode intensity of the stimuli
changes with the stimuli
amplitude for intensity
how do the receptor action potential encode intensity of the stimuli
changes with the receptor graded potential
frequency for intensity
how does transduction of receptors work
stimulants are neurotransmitters from the stimuli that bind with receptor cells or nerve endings
what channels/receptors are used for post synaptic membrane
ionotropic receptor: ligand/modality gated ion channels
metabotropic receptor: G protein coupled receptors
what are the effects when transduction occurs at the receptors
excitatory: EPSP, depolar
inhibitory: IPSP, hyperpolar
where is the potential initiated if receptor is a cell
receptor graded potential close to soma of sensory system
where is the potential initiated if receptor is a specialized/free nerve ending
receptor graded potential far away from soma of sensory system
what is the function of the meissner corpuscle
flutter and movement
vibration
what is the function of the pacinian corpuscle
vibration
what is the function of the ruffini corpuscle
skin stretch
what is the function of the hair follicle
movement
what is the function of the merkel complex
touch, pressure, form, perceiving edges
what is the function of free nerve endings
pain, touch, temperature
what cutaneous receptors are rapid adapting receptors
meissner, pacinian and hair follicle
what cutaneous receptors are slow adapting receptors
ruffini and merkel complex
what are rapid adapting receptors
produce graded and action potential discharges that follow time varying waveform of pressure changes produced by vibration
ex. vibration or movement
what are slow adapting receptors
produce graded and action potential discharges that are sustained and unable to mimic the time-varying pattern of the stimulus
ex. sustain pressure
what cutaneous receptors have type II/AB
meissner
pacinian
ruffini
hair follicle
merkel
what cutaneous receptors have type III/Ao
free nerve ending
what cutaneous receptors have type II/AB and III/Ao
hair follicle
what is unique about Ab neuron axons in the skin
large diameter, myelinated axons with fast conduction
most on lips and fingertips
what clinical test is used for fine touch to test the cutaneous receptors
2 pt discrimination
what is the function and type of the muscle spindle
muscle stretch
1a/Aa or II/AB
what is the function and type of the GTO in the m
muscle tension
Ib/Aa
what is the function and type of the jt pacinian
jt movement
II/AB
what is the function and type of the jt ruffini
jt pressure
II/AB
what is the function and type of the GTO in the jt
jt torque
II/AB
what proprioceptive receptors are slow adapting receptors
m spindle
m GTO
jt ruffini
jt GTO
what proprioceptive receptors are fast adapting receptors
m spindle
jt pacinian
what are the structural m fibers
nuclear chain and bag cells
what is the extrafusal m cell
alpha neuron cell
what is the intrafusal m cell
gamma motor neuron
type 1a (Aa) or 1b (AB) sensory neuron innervation for proprioception and motor
what is the clinical test for vibration in the skeletal m cells
tuning fork
128 Hz
pacinian type
what is the DCML ascending pathway
1- DRG
2- caudal medulla; gracile nucleus or cuneate nucleus
3- VPL
what is the function of the shell and core for VPM/L
shell- proprioception
core- vibration/fine touch
what is the clinical importance of DCML somatotopy being maintained
brialle reading
stereognosis test
what is the blood supply before decussation in DCML
dorsal column
neck to LE- lat to med
post sp artery
what is the blood supply after decussation in the pons of the DCML
medial leminscus
neck to LE- med to lat
INVERTED
basilar branch, PICA, AICA
what is the blood supply after decussation in the rostral medulla of the DCML
medial leminscus
neck to lE- post to ant
ant sp artery
what is DCML functional loss
Tabes Dorsalis
progressive locomotor ataxia/sensory ataxia
what causes Tabes Dorsalis and the physiology
infection with treponemaa pallidum (STD) resulting in neurosyphillis
DCML degeneration
what are S&S of Tabes Dorsalis
wide based stance/ feet grasping with floor/steppage gait
what is the trigeminothalamic pathway for face and ant scalp
- somata: trigeminal ganglion or mesencephalic nucleus
2- main sensory nucleus
3- VPM
what is the function of the trigeminal ganglion in the trigeminothalamic pathway
fine touch, vibration, limited proprioception
what is the function of the mesencephalic nucleus in the trigeminothalamic pathway
proprioception of m/jt/peridontal ligaments
what is the brodman area for proprioception
3a= m spindle and GTO
2= jt capsule
what functions are for brodman areas 3b and 1
fine/crude touch
sharp pain/temp
what is the pathway for the mesencephalic nucleus in the trigeminocerebellar pathway
ipsi cerebellum thru sup cerebellar peduncle
mossy or climbing fibers
what is the pathway for the sp trigeminal nucleus in the trigeminocerebellar pathway
ipsi cerebllum thru inf cerebellar peduncle
climbing fibers
where does the ant spinocerebellar tract decussate and then ascend to
after clarke’s nucleus thru ant white commisure to ascend contra to spinocerebellum
where does the ant spinocerebellar tract go through
sup cerebellar peduncle
bilateral
mossy or climbing fibers
where does the rostral spinocerebellar tract go through
sup/inf cerebellar peduncle
mossy or climbing fibers
where do the proprioceptive axons synapse in the post spinocerebellar tract
clarkes nucleus
what is the pathway for unconscious proprioception
ascend ipsi thru inf cerebellar peduncle to spinocerebellum
mossy or climbing fibers
what body regions does the post spinocerebellar and cuneocerebellar tract control for unconscious proprioception
post- LE and body
cuneo- neck