Lecture 2: Ss system- DCML Flashcards

1
Q

what is a macroscopically

A

structures that detect stimuli

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2
Q

what is a microscopically

A

molecules interacting with the stimuli

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3
Q

what is the breakdown for a receptor

A

directly detecting a stimuli, rich in mitochondria
1. cell so a neuron (olfactory receptor neuron) or non-neuron ccell (hair, rods/cones, merkel)
2. nerve ending so specialized capsules or free nerve ending

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4
Q

what does a mechanoreceptor detect

A

touch
vibration
stretch

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5
Q

what does a chemoreceptor detect

A

taste
smell
pH
O2

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6
Q

what does a thrmoreceptor detect

A

cold to hot
flavor of food

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7
Q

what does a nociceptor detect

A

noxious stimuli

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8
Q

what is the function of free nerve endings

A

functions of all receptors
differentiated through electric stimulation

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9
Q

what is special sensory receptors

A

electromagnetic waves such as rods/cones

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10
Q

how is conscious localization maintained

A

projecting to S1 to maintain somatotopy

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11
Q

how is unconscious localization maintained

A

projecting to subcortical structures
RF or cerebellum

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12
Q

how do the receptors encode duration of the stimuli

A

receptor graded potential is what measures duration. when the stimuli stops so does the receptor graded potential. however, it can have lagging effects

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13
Q

how do the receptor graded potential encode intensity of the stimuli

A

changes with the stimuli
amplitude for intensity

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14
Q

how do the receptor action potential encode intensity of the stimuli

A

changes with the receptor graded potential
frequency for intensity

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15
Q

how does transduction of receptors work

A

stimulants are neurotransmitters from the stimuli that bind with receptor cells or nerve endings

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16
Q

what channels/receptors are used for post synaptic membrane

A

ionotropic receptor: ligand/modality gated ion channels
metabotropic receptor: G protein coupled receptors

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17
Q

what are the effects when transduction occurs at the receptors

A

excitatory: EPSP, depolar
inhibitory: IPSP, hyperpolar

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18
Q

where is the potential initiated if receptor is a cell

A

receptor graded potential close to soma of sensory system

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19
Q

where is the potential initiated if receptor is a specialized/free nerve ending

A

receptor graded potential far away from soma of sensory system

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20
Q

what is the function of the meissner corpuscle

A

flutter and movement
vibration

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21
Q

what is the function of the pacinian corpuscle

A

vibration

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22
Q

what is the function of the ruffini corpuscle

A

skin stretch

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23
Q

what is the function of the hair follicle

A

movement

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24
Q

what is the function of the merkel complex

A

touch, pressure, form, perceiving edges

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25
Q

what is the function of free nerve endings

A

pain, touch, temperature

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26
Q

what cutaneous receptors are rapid adapting receptors

A

meissner, pacinian and hair follicle

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27
Q

what cutaneous receptors are slow adapting receptors

A

ruffini and merkel complex

28
Q

what are rapid adapting receptors

A

produce graded and action potential discharges that follow time varying waveform of pressure changes produced by vibration

ex. vibration or movement

29
Q

what are slow adapting receptors

A

produce graded and action potential discharges that are sustained and unable to mimic the time-varying pattern of the stimulus

ex. sustain pressure

30
Q

what cutaneous receptors have type II/AB

A

meissner
pacinian
ruffini
hair follicle
merkel

31
Q

what cutaneous receptors have type III/Ao

A

free nerve ending

32
Q

what cutaneous receptors have type II/AB and III/Ao

A

hair follicle

33
Q

what is unique about Ab neuron axons in the skin

A

large diameter, myelinated axons with fast conduction

most on lips and fingertips

34
Q

what clinical test is used for fine touch to test the cutaneous receptors

A

2 pt discrimination

35
Q

what is the function and type of the muscle spindle

A

muscle stretch
1a/Aa or II/AB

36
Q

what is the function and type of the GTO in the m

A

muscle tension
Ib/Aa

37
Q

what is the function and type of the jt pacinian

A

jt movement
II/AB

38
Q

what is the function and type of the jt ruffini

A

jt pressure
II/AB

39
Q

what is the function and type of the GTO in the jt

A

jt torque
II/AB

40
Q

what proprioceptive receptors are slow adapting receptors

A

m spindle
m GTO
jt ruffini
jt GTO

41
Q

what proprioceptive receptors are fast adapting receptors

A

m spindle
jt pacinian

42
Q

what are the structural m fibers

A

nuclear chain and bag cells

43
Q

what is the extrafusal m cell

A

alpha neuron cell

44
Q

what is the intrafusal m cell

A

gamma motor neuron
type 1a (Aa) or 1b (AB) sensory neuron innervation for proprioception and motor

45
Q

what is the clinical test for vibration in the skeletal m cells

A

tuning fork
128 Hz
pacinian type

46
Q

what is the DCML ascending pathway

A

1- DRG
2- caudal medulla; gracile nucleus or cuneate nucleus
3- VPL

47
Q

what is the function of the shell and core for VPM/L

A

shell- proprioception
core- vibration/fine touch

48
Q

what is the clinical importance of DCML somatotopy being maintained

A

brialle reading
stereognosis test

49
Q

what is the blood supply before decussation in DCML

A

dorsal column
neck to LE- lat to med
post sp artery

50
Q

what is the blood supply after decussation in the pons of the DCML

A

medial leminscus
neck to LE- med to lat
INVERTED
basilar branch, PICA, AICA

51
Q

what is the blood supply after decussation in the rostral medulla of the DCML

A

medial leminscus
neck to lE- post to ant
ant sp artery

52
Q

what is DCML functional loss

A

Tabes Dorsalis
progressive locomotor ataxia/sensory ataxia

53
Q

what causes Tabes Dorsalis and the physiology

A

infection with treponemaa pallidum (STD) resulting in neurosyphillis
DCML degeneration

54
Q

what are S&S of Tabes Dorsalis

A

wide based stance/ feet grasping with floor/steppage gait

55
Q

what is the trigeminothalamic pathway for face and ant scalp

A
  1. somata: trigeminal ganglion or mesencephalic nucleus
    2- main sensory nucleus
    3- VPM
56
Q

what is the function of the trigeminal ganglion in the trigeminothalamic pathway

A

fine touch, vibration, limited proprioception

57
Q

what is the function of the mesencephalic nucleus in the trigeminothalamic pathway

A

proprioception of m/jt/peridontal ligaments

58
Q

what is the brodman area for proprioception

A

3a= m spindle and GTO
2= jt capsule

59
Q

what functions are for brodman areas 3b and 1

A

fine/crude touch
sharp pain/temp

60
Q

what is the pathway for the mesencephalic nucleus in the trigeminocerebellar pathway

A

ipsi cerebellum thru sup cerebellar peduncle
mossy or climbing fibers

61
Q

what is the pathway for the sp trigeminal nucleus in the trigeminocerebellar pathway

A

ipsi cerebllum thru inf cerebellar peduncle
climbing fibers

62
Q

where does the ant spinocerebellar tract decussate and then ascend to

A

after clarke’s nucleus thru ant white commisure to ascend contra to spinocerebellum

63
Q

where does the ant spinocerebellar tract go through

A

sup cerebellar peduncle
bilateral
mossy or climbing fibers

64
Q

where does the rostral spinocerebellar tract go through

A

sup/inf cerebellar peduncle
mossy or climbing fibers

65
Q

where do the proprioceptive axons synapse in the post spinocerebellar tract

A

clarkes nucleus

66
Q

what is the pathway for unconscious proprioception

A

ascend ipsi thru inf cerebellar peduncle to spinocerebellum
mossy or climbing fibers

67
Q

what body regions does the post spinocerebellar and cuneocerebellar tract control for unconscious proprioception

A

post- LE and body
cuneo- neck