Lecture 2 - Hypothalamus/Pituitary 2

Question 1

Oestrogen signalling?

Answer 1

classical (cytoplasmic receptor -> nucleus) and non-classical (involvement of signalling cascade)

Question 2

CREB?

Answer 2

enzyme inhibited by oestrogen in GnRH neurons

Question 3

Kisspeptin regulation of GnRH neuron activity during puberty?

Answer 3

positive feedback RP3V, negative feedback ARN

Question 4

Acromegaly condition?

Answer 4

increased somatotrophin and failure to decrease blood glucose in oral glucose challenge test

Question 5

Acromegaly presentations?

Answer 5

enlarged pituitary, headache, increased BP, protruding jaw and enlarged small bones (hands and feet)

Question 6

Idiopathic central precocious puberty?

Answer 6

mutation of proline into arginine, leading to prolonged intracellular signalling pathways related to kisspeptin, increasing amplitude pulse of GnRH

Question 7

Kallman syndrome?

Answer 7

GnRH deficiency leading to delayed/absent puberty and bone weakness