Lecture 1 - Hypothalamus/Pituitary 1

Question 1

Development?

Answer 1

forebrain -> diencephalon -> hypothalamus

Question 2

Blood vessels - anterior pituitary

Answer 2

superior hypophyseal artery -> hypophyseal portal veins -> anterior hypophyseal veins

Question 3

Blood vessels - posterior pituitary?

Answer 3

inferior hypophyseal artery -> capillary plexus of infundibular process -> posterior hypophyseal vein

Question 4

Axons of the posterior pituitary>?

Answer 4

non-myelineated for neurosecretory purposes, cell bodies in the hypothalamus

Question 5

Growth hormone inhibiting hormone pathway?

Answer 5

periventricular nucleus release GHIH which inhibits anterior lobe releasing GH stimulating liver which leads to (decreased) skeletal muscle, cartilage and other tissue growth - IGF-1 positively feedsback

Question 6

Growth hormone releasing hormone pathway?

Answer 6

arcuate nucleus release GHRH stimulating anterior lobe, releasing GH which stimulates liver - IGF-1 negatively feeds back

Question 7

Prolactin?

Answer 7

ilk production - anterior lobe

Question 8

Oxycotin?

Answer 8

milk letdown - posterior lobe

Question 9

Positive feedback of titties?

Answer 9

suckling on mammary gland triggers signal up spinal cord, positively feeding back further release

Question 10

Tubero-infundibular dopamine neurons?

Answer 10

prolactin positively feeds back these neurons increasing DA in median eminence inhibiting prolactin production - placental lactogens inhibit DA

Question 11

Gonad hormones and ovary cells?

Answer 11

LH acts on thecal cells, FSH act on granulosa cells