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AU2017 Gen Path Exam 3 > Lecture 2- Gastrointestinal Pathology 2 > Flashcards

Lecture 2- Gastrointestinal Pathology 2 Flashcards

1
Q

most common polyposis syndrome of the GI tract?

2nd most common?

A

Familial Adenomatous Polyposis

Peutz Jegher syndrome

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2
Q

risk of affect patients of FAP developing colon cancer approaches…

A

100%

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3
Q

…. requires more than or equal to 100 polyps to diagnose

A

FAP

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4
Q

gardner’s syndrome is …. + …

A

FAP

extraintestinal lesions

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5
Q

oral manifestations of Gardners syndrome

A 
unerupted teeth
supernumerary teeth
mandib. cysts
inc. risk for odontomas
delayed tooth eruption
skin lesions
CHRPE
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6
Q

… is the 2nd most common polyposis syndrome

A

Peutz Jegher syndrome

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7
Q

… syndrome presents with melanin deposits around nose, lips, buccal mucosa, hands and feet, genitalia and perianal region. develop early in childhood

A

Peutz Jegher

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8
Q

in idiopathic inflammatory bowel disease, … can occur in any portion of the GI tract starting with the mouth and …. is localized to the colon and rectum only

A

crohns disease

ulcerative colitis

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9
Q

… are extensions into the colonic lumen that are hyperplastic, inflammatory, hamartomatous and adenomatous

A

colon polyps

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10
Q

what is the most important predictor of malignant change in adenomas in the colon?

A

size

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11
Q

familail adenomatous polyposis entails mutations of the … gene

A

APC

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12
Q

estimated penetrance for adenomas in FAP is greater than …%

A

90%

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13
Q

untreated polyposis leads to …% risk of cancer

A

100%

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14
Q

CHRPE is…

A

congenital hypertrophy of retinal pigment epithelium

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15
Q

2 polyposis associated syndromes with oral manifestations

A

Gardeners (FAP + extraintestinal lesions)

Peutz Jegher syndrome

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16
Q

a common feature of …. is non-sun dependent freckling of the skin around the lips and the vermillion zone of the lips

A

Peutz-Jeghers syndrome

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17
Q

…. involves GI hamartomatous polyps (intussusception) and pigmented macules of mucous membranes and skin

A

Peutz-jeghers

18
Q

average age of dx for peutz-jeghers?

A

23-26

19
Q

name 2 idiopathic inflammatory diseases

A

crohns

ulcerative colitis

20
Q

… disease presents with chronic diarrhea +/- blood with colicky abdominal pain and presents in young adulthood

A

crohns

21
Q

crohns disease can affect any portion of the GI tract , most often is seen in … and …

A

distal small bowel (ileum)

colon

22
Q

T/F oral involvement is often seen in crohns

A

true

23
Q

… disease is a segmented transmural inflammation of the bowel

A

crohns

24
Q

ulcerative colitis only affects the … and …

A

colon

rectum

25
Q

T/F oral involvement is often seen in ulcerative colitis

A

false. its rare

26
Q

in crohns disease you will often see “…” lesions and the bowel wall be …

A

skip

thick, stenotic

27
Q

crohns or UC?

mucosal ulcer “cobblestone” diseased tissue lower than normal tissue

A

crohns

28
Q

benign stomach tumors

A

inflammatory or reactive

leiomyomas

29
Q

malignant stomach tumors

A

adenocarcinoma (90-95%)

lymphoma (4%)

carcinoid (3%)

spindle cell tumors (2%)

30
Q

gastric carcinoma represents …% of all cancer deaths

A

3%

31
Q

most important prognostic indicators in adenocarcinoma of the colon?

A

depth of invasion and lymph node metastases

32
Q

TMN classification

A

T: depth of tumor

  1. submucosa
  2. muscularis propia
  3. subserosa/pericolic fat
  4. contiguous structures

N: lymph nodes
M: metastasis

33
Q

which presents with noncaseating granulomas? crohns or ulcerative colitis?

A

crohns

34
Q

UC is related to crohns but UC is limited to the … and always involves the …

A

colon

rectum

35
Q

what is the term for this oral manifestation that can be seen in either UC or crohns:

scattered, arc-shaped pustules on an erythematous mucosa at multiple oral sites with variable severity.

A

“snail track” or pyostomatitis vegetans

36
Q

in UC, 10% of patients develop IBD-associated arthritis of ….

A

temporomandibular joints

37
Q

2 benign small intestine tumors

A

adenoma

leiomyoma

38
Q

4 malignant small intestine tumors

A

adenocarcinoma
carcinoid
lymphoma
sarcoma

39
Q

most common malignancy of the GI tract?

A

colon adenocarcinoma

40
Q

what kind of diet is a risk factor for colorectal cancer?

A

high fat, low fiber

41
Q

colorectal cancer is responsible for causing …% of all cancer deaths in the US and is second only to lung cancer in cancer deaths

A

15

42
Q

there is an increased incidence of adenocarcinoma of the colon in … patients

A

FAP

AU2017 Gen Path Exam 3 (12 decks)

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