Lecture 2- Gastrointestinal Pathology 2 Flashcards
most common polyposis syndrome of the GI tract?
2nd most common?
Familial Adenomatous Polyposis
Peutz Jegher syndrome
risk of affect patients of FAP developing colon cancer approaches…
100%
…. requires more than or equal to 100 polyps to diagnose
FAP
gardner’s syndrome is …. + …
FAP
extraintestinal lesions
oral manifestations of Gardners syndrome
unerupted teeth supernumerary teeth mandib. cysts inc. risk for odontomas delayed tooth eruption skin lesions CHRPE
… is the 2nd most common polyposis syndrome
Peutz Jegher syndrome
… syndrome presents with melanin deposits around nose, lips, buccal mucosa, hands and feet, genitalia and perianal region. develop early in childhood
Peutz Jegher
in idiopathic inflammatory bowel disease, … can occur in any portion of the GI tract starting with the mouth and …. is localized to the colon and rectum only
crohns disease
ulcerative colitis
… are extensions into the colonic lumen that are hyperplastic, inflammatory, hamartomatous and adenomatous
colon polyps
what is the most important predictor of malignant change in adenomas in the colon?
size
familail adenomatous polyposis entails mutations of the … gene
APC
estimated penetrance for adenomas in FAP is greater than …%
90%
untreated polyposis leads to …% risk of cancer
100%
CHRPE is…
congenital hypertrophy of retinal pigment epithelium
2 polyposis associated syndromes with oral manifestations
Gardeners (FAP + extraintestinal lesions)
Peutz Jegher syndrome
a common feature of …. is non-sun dependent freckling of the skin around the lips and the vermillion zone of the lips
Peutz-Jeghers syndrome
…. involves GI hamartomatous polyps (intussusception) and pigmented macules of mucous membranes and skin
Peutz-jeghers
average age of dx for peutz-jeghers?
23-26
name 2 idiopathic inflammatory diseases
crohns
ulcerative colitis
… disease presents with chronic diarrhea +/- blood with colicky abdominal pain and presents in young adulthood
crohns
crohns disease can affect any portion of the GI tract , most often is seen in … and …
distal small bowel (ileum)
colon
T/F oral involvement is often seen in crohns
true
… disease is a segmented transmural inflammation of the bowel
crohns
ulcerative colitis only affects the … and …
colon
rectum
T/F oral involvement is often seen in ulcerative colitis
false. its rare
in crohns disease you will often see “…” lesions and the bowel wall be …
skip
thick, stenotic
crohns or UC?
mucosal ulcer “cobblestone” diseased tissue lower than normal tissue
crohns
benign stomach tumors
inflammatory or reactive
leiomyomas
malignant stomach tumors
adenocarcinoma (90-95%)
lymphoma (4%)
carcinoid (3%)
spindle cell tumors (2%)
gastric carcinoma represents …% of all cancer deaths
3%
most important prognostic indicators in adenocarcinoma of the colon?
depth of invasion and lymph node metastases
TMN classification
T: depth of tumor
- submucosa
- muscularis propia
- subserosa/pericolic fat
- contiguous structures
N: lymph nodes
M: metastasis
which presents with noncaseating granulomas? crohns or ulcerative colitis?
crohns
UC is related to crohns but UC is limited to the … and always involves the …
colon
rectum
what is the term for this oral manifestation that can be seen in either UC or crohns:
scattered, arc-shaped pustules on an erythematous mucosa at multiple oral sites with variable severity.
“snail track” or pyostomatitis vegetans
in UC, 10% of patients develop IBD-associated arthritis of ….
temporomandibular joints
2 benign small intestine tumors
adenoma
leiomyoma
4 malignant small intestine tumors
adenocarcinoma
carcinoid
lymphoma
sarcoma
most common malignancy of the GI tract?
colon adenocarcinoma
what kind of diet is a risk factor for colorectal cancer?
high fat, low fiber
colorectal cancer is responsible for causing …% of all cancer deaths in the US and is second only to lung cancer in cancer deaths
15
there is an increased incidence of adenocarcinoma of the colon in … patients
FAP
