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AU2017 Gen Path Exam 3 > Lecture 12- Skin diseases > Flashcards

Lecture 12- Skin diseases Flashcards

1
Q

a … is a flat circumscribed area less than 5 mm

A

macule

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2
Q

a … is a flat circumscribed area greater than 5 mm

A

patch

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3
Q

a … is an elevated lesion that is less than 5 mm

A

papule

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4
Q

a … is an elevated lesion that is greater than 5 mm

A

plaque

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5
Q

a … is a discrete pus-filled lesion

A

pustule

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6
Q

a … is a fluid filled lesion less than 5 mm

A

vesicle

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7
Q

a … is a fluid filled lesion greater than 5 mm

A

bulla

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8
Q

3 acute inflammatory dermatoses

A

urticaria
acute eczema
erythema multiforme

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9
Q

clinical features of …. are erythematous, edematous, and pruritic papules and plaques (wheals)

A

urticaria

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10
Q

individual hive last …. but episodes can continue for …

A

less than 24 hrs

weeks

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11
Q

pathogenesis of acute urticaria

A

mast cell degranulation–> increased dermal vascular permeability–> dermal edema

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12
Q

urticaria is which type of hypersensitivity?

A

immediate type 1 (IgE)

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13
Q

inciting factor of urticaria

A

medications (opiates, abx)

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14
Q

tx of urticaria

A

antihistamines

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15
Q

clinical features of … are pruritic inflammatory erythematous papules and scaly plaques that can become vesicular and crusted

A

acute eczema

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16
Q

with acute eczema, skin thickens over time due to…

A

acanthosis

17
Q

in acute eczema you see …. on histo: epidermal edema, perivascular lymphocytic infiltrate and mast cell degranulation

A

spongiotic dermatitis

18
Q

types of eczema

A

atopic
allergic contact
photoezematous
irritant dermatitis

19
Q

…. eczema usually has a genetic predisposition and has a triad with allergies and asthma and is is more common in childhood, outgrow as adult

A

atopic

20
Q

allergic contact dermatitis is a type … hypersensitivity rxn and is … mediated ( poison ivy)

A

IV

CD4+T

21
Q

… is a hypersensitivity rxn due to medications such as sulfonamides, PCN, NSAIDS, hydroxyquinone and infections such as HSV and mycoplasma

A

erythema multiforme

22
Q

erythema multiforme is on the spectrum of

A

stevens johnson (mucosal involvement) and toxic epidermal necrolysis (TEN- full thickness epidermal necrosis)

23
Q

classic feature of erythema multiforme

A

targetoid lesion

24
Q

… is a chronic inflammatory dermatosis that affects 1-2% of the US population and is associated with heart disease and 10% can develop arthritis

A

psoriasis

25
Q

psoriasis is …. mediated

A

T cell (autoimmune)

26
Q

clinical features of …. are erythematous salmon-pink colored plaques with silvery scale. affected areas are usually the extensor elbows, knees, scalp, gluteal cleft. you will also see nail thickening and dystrophy

A

psoriasis

27
Q

… is when you can induce a lesion by local trauma in psoriasis

A

koebner or koebnerization

28
Q

a … is when you get punctate bleeding when overlying scale is removed

A

auspitz sign

29
Q

… is caused by staph or strep pyogenes and is very contagious, more common in kids spreads by direct contact. starts as small macule often perioral/perinasal and enlarges with honey-colored crust (dried serum)

A

impetigo

30
Q

tx for impetigo

A

antibiotics

31
Q

3 blistering dermatoses

A

pemphigus vulgaris

pemphigus foliaceus

bullous pemphigoid

32
Q

… is lysis of intercellular jxns between squamous cells

A

acantholysis

33
Q

pemphigus… shows suprabasal acantholysis which means above basal cell

A

vulgaris

34
Q

pemphigus … shows acantholysis subcorneal which means superficial epidermis at stratum granulosum

A

foliaceus

35
Q

pemphigus is a type … hypersensitivity rxn and involves … autoantibodies that bind to …. intercellular desmosomal proteins

A

2

IgG

desmoglein type 1 and 3

36
Q

most common type of skin cancer

A

basal cell carcinoma

37
Q

Pruritic, purple, polygonal, and planar papules and plaques describes what?

A

lichen planus

AU2017 Gen Path Exam 3 (12 decks)

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