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Zak, Cells > Lecture 2 > Flashcards

Lecture 2 Flashcards

0
Q

Basal Lamina

A

Created by Epithelium
Includes: Laminin, Type IV Collagen, Proteoglycans, & Entactin
Binding Site for: Integrins, Type IV Collage, Proteoglycans, & Entactin

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1
Q

Components of the Basement Membrane

A

Basal Lamina

Reticular Lamina

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2
Q

Reticular Lamina

A

Created by connective tissue

Non-fibrous

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3
Q

Fibronectin

A

2 forms: Cellular & Plasma

Binding sites for: Heparin (Proteoglycan), Integrins, Collagen, & Fibrin

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4
Q

Cellular Fibronectin

A

Produced by fibroblasts, part of extracellular matrix

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5
Q

Plasma Fibronectin

A

Secreted into bloodstream by hepatocytes

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6
Q

CAM’s

A

Cell Adhesion Molecules

2 types: Ca++ dependent & Ca++ independent

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7
Q

Ca++ Dependent CAM’s

A

Cadherins & Selectins

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8
Q

Ca++ Independent CAM’s

A

Integrins & Immunoglobulin Superfamily

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9
Q

Cadherins

A

Classical & Non-classical

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10
Q

Classical Cadherins

A

Form Cis- & Trans- homophilic dimers
Cis: within the same cell
Trans: cell-cell
Include E, N, & P Cadherins: Epithelial, Nerve, Placenta

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11
Q

Nonclassical Cadherins

A

Found in Desmosomes

Include Desmocollins & Desmogleins

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12
Q

E-Cadherins

A

Trans-membrane molecules

Form dimers using HVA binding sites

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13
Q

HVA binding sites

A

Facilitate formation of trans-homophilic dimers with cadherins of neighboring cell

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14
Q

Catenins

A

Small proteins that link cytoplasmic end of cadherin with cytoplasmic actin

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15
Q

Selectins

A

Contain Carbohydrate Recognition Domain (CRD) at extracellular end that bind to carbohydrates
Ca++ binding sites also near CRD, Ca++ required for binding to occur
Involved in moving leukocytes out of blood stream (extravasation)

16
Q

Types of Selectins

A

P-platelet selectins
E-endothelial selectins
L-leukocytes

17
Q

Integrins

A

Glycoproteins involved in cell-extracellular matrix interactions
Bind to extracellular matrix and cytoskeleton
Bind to Fibronectin and Laminin in extracellular matrix

18
Q

Where are Laminin and Fibronectin located and what do they interact with…

A

Located in basement membrane

Interact with Collagen, Heparan Sulfate Proteoglycans, & Entactin

19
Q

Hemidesmosomes/Desmosomes

A

Hemidesmosomes- only at basal domain, attach via extracellular matrix and tonofilaments (keratin) in intracellular matrix
Desmosomes- bind one cell to a neighboring cell

20
Q

Immunoglobulin Superfamily

A

Posses an extracellular segment with one or more folded domains

21
Q

Members of the Ig-Superfamily

A

N-CAMs: neural adhesion molecules that aid in homo- and hetero- philic interactions
I-CAM-1 & I-CAM-2: facilitate transendothelial transport of leukocytes

22
Q

Adherens

A

Molelcular complexes that anchor cells together and reinforce physical integrity of tissues
Found on basolateral surface of epithelial cells

23
Q

Occludens

A

Molecular complexes that establish an impermeable membrane b/w cells that prohibits paracellular transport

24
Q

Gap Junctions

A

Pores in cells that allow for quick exchange of small molecules/ions
Can be added or taken out of cell when necessary
Composed of Connexons which consist of 6 Connexins in hexagonal structure
Close when [Ca++] is high

25
Q

Zonula Adheren

A

Type of junctional complex
aka Belt-like complexes
Travel full circumference of cell attaching all neighboring cells to a central cell
Associated with actin microfilaments

26
Q

Macula Adheren

A

Type of junctional complex
“Spot” adherens referred to as Desmosomes (lateral sides)/Hemidesmosomes (basal side) of epithelial cells
Associated with tonofilaments

27
Q

Zonula Occluden

A

Belt-like, tight junctions that provide of barrier against the paracellular transport pathway

28
Q

JAM’s

A

Junctional Adhesion Molecules
Part of immunogloblulin superfamily
Form cis- homodimers that facilitate adhesion

29
Q

Nectin

A

Part of immunoglobulin superfamily

Form cis- homodimers to facilitate adhesion

30
Q

Focal Adhesions

A

Spots that anchor the cell to the extracellular matrix via integrins
Bind to actin intracellularly, unlike desmosomes which bind to tonofilaments

Zak, Cells (17 decks)

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