Lecture 19 - Adrenal Medulla

Question 1

Epi and Norepi are cetecholamine hormones. Their synth is as follows:

_____ is converted by ____ ____ in the Cytoplasm to DOPA –> converted to ______ by the enzyme _______ in the Cytoplasm –> taken up by granules and converted to ______ by the enzyme _______ –> Diffuses back into cytoplasm and is converted to _____ by the enzyme ______ –> taken back into granules for secretion.

Answer 1

Tyrosine

Tyrosine Hydroxylase

Dopamine

AAD (amino acid decarboxylase)

Norepi

Dopamine Beta-hydroxylase

Epi

PNMT

Question 2

Epi mainly acts via _____ adrenergic receptors to increase _____, while Norepi mainly acts via _____ adrenergic receptors to increase free _____.

Answer 2

Alpha adrenergic

cAMP

Beta adrenergic

Ca++

Question 3

Epi and Norepi increase gluconeo in the _____ and release of _____ from muscles via glycogenolysis.

Answer 3

Liver

Lactate

Question 4

Ach from preganglionic sympathetic neurons stimulates both the production AND ______ of Epi and Norepi.

Answer 4

Exocytosis

Question 5

Epi and Norepi half-life is about ___-___ mins.

Answer 5

1-3mins