Lecture 15 - Calcium Pharmacology

Question 1

_______ can be given for treatment of Hypocalcemia in patients with Kidney disease bc it is already hydroxylated at the 1 position (no need for 1alpha-hydroxylase).

_______ is the same thing but is the VitD2 derivative.

Answer 1

Alphacalcidol

Doxecalciferol

Question 2

_______ is used to treat secondary hyperparathyroidism as it does not have any effect on bone resorption, but it DOES inhibit PTH.

Answer 2

Paricalcitol

Question 3

Calcipotriol does not affect Ca++ metabolism, though it has similar affinity for VitD receptor as calcitriol. What is it used to treat?

Answer 3

It is used topically to treat Psoriasis.

Question 4

Cinacalcet sensitizes the Ca++ receptor of Chief cells that secrete PTH, thus it inhibits PTH at ______ (higher or lower?) free Ca++ serum levels. It can be used to treat either Primary or Secondary Hyperparathyroidism, primarily in patients with ______ ______ failure. Just keep in mind the preferred treatment for Primary Hyperparathyroidism is ______.

Answer 4

Lower

Chronic Renal Failure

Surgery

Question 5

Raloxifene does increase the risk of _____, though it decreases the risk of _____ cancer.

Answer 5

DVT

Breast cancer

Question 6

Estrogen acts to directly decrease RANKL production in Osteoblasts and Osteocytes, but it also INCREASES the production of _______, which binds RANKL, inhibiting it from binding RANK on Osteoclasts.

Answer 6

Osteoprotegerin (OPG)

Question 7

Denosumab has been shown to decrease both _____ and non-_____ fractures.

Answer 7

Vertebral and Non-vertebral

Question 8

Teriparatide should not be used in patients with ____ disease, bc it would exacerbate bone remodeling issues.

Answer 8

Paget’s disease