Lecture 10 and 11 - Pharmacology of Thyroid Flashcards
1
Q
Iodide enters Thyroid follicular cells via a ___/____ symporter and is transported into the follicular lumen via _____, a Cl-/I- antiporter.
A
Na+/I- symporter
Pendrin
2
Q
_____ (levothyroxine) is the recommended treatment for chronic Hypothyroidism. Its half-life is about ____days (administered once per day), which is in stark contrast to ____ (liothyronine) which has a half-life of about ____hrs (making it difficult to maintain constant levels, but it is good for hypothyroid emergencies).
A
T4
7days
T3
24hrs
3
Q
How long does it take for the therapeutic effects of PTU and Methimazole to be observed and why?
A
About 3-4 weeks bc they block TPO, and thus the synth of T4 and T3, but there are huge stores of T4 and T3 in the thyroid that take 3-4 weeks to deplete.
