Lecture 19 Flashcards
O2 is carried in two forms. What are they?
- Dissolved O2
2. Bound to hemoglobin in Red blood cells.
Why does the hemoglobin curve shift to the left?
Curve shifts left with increasing pH and hemoglobin releases less oxygen
Why does the hemoglobin curve shift to the right?
Because of decreasing pH and hemoglobin releases more oxygen
Why does O2-Haemoglobin saturation curve have a sigmoidal shape?
The flat-top part prevents fluctuation O2. The steep slope allows for haemoglobin to take more O2 and release it.
Why does the sigmoidal shape of the curve help hemoglobin to deliver oxygen to tissues that need it most?
The partial pressure of O2 is high in the pulmonary capillaries allowing more molecules of O2 to bind hemoglobin until reaching maximum concentration
Hugo goes to the gym and runs on the treadmill. What is most likely to happen as she is exercising?
His haemoglobin affinity for O2 near her skeletal muscle is decreased
How do pH and temperature affect the haemoglobin binding curve?
Consuming more O2 during exercise, producing more CO2. Hemoglobin loses its affinity to bind to O2 therefore more O2 is released. pH will change causing it to move to the right.
What 3 ways is CO2 transported in?
- Dissolved in plasma
- Biocarbonate
- Combined with proteins as carbamino compounds
The central controller receives ____signals from the sensors (chemo and baro) then sends _____signals to the effectors
afferent, efferent
Baroreceptors:
Send signals when there are any changes in blood pressure.
What happens if arterial blood pressure goes up?
Respiratory minute volume goes down and there is a decreased uptake of air
