Lecture 18 Flashcards
chronic stress = _____ CRH + GC (where for each)
increased CRH in brain, increase GC basally
chronic exposed to GC =
damage to hippocampus, decreased GC negative feedback, increase HPA axis activity
- increase CRH in brain
- increase GC basally
- increase in adrenal gland size
chronic stress affects NTs:
serotonin, norepinephrine, GABA, benzos
chronic stress on CNS
drug seeking behaviours, impairment of memory, increased anxiety, learned helplessness
chronic stress hippocampal damage
shrinkage of neurons, shrinkage of soma
ex of mutant of GC receptor gene
Leu753Met, strongly decreased sensitivity, GC resistance syndrome
in stable environment, dominant male monkeys have _______ GC levels
lower
in unstable environments, dominant male monkeys have _______ GC levels
higher
dominant males with these personality traits have lowest GC levels
high degree of social control, predictability, and outlets for frustration
Hans Selye - genreal adaptation syndrome
alarm (fight/flight), resistance (after several days adapt to stress), exhaustion (body breaks down)
allostasis happens in which part of Hans Selye general adaptation syndrom
resistance
is second stressor added during _____ phase, organism dies
resistance
w/ threat (vs. challenge)
decreased blood flow to brain, decreased blood to effector muscles, decreased cognitive and physical performance
enhanced memory w/ ______ stressor
mild
mother grooming = _____ GR = ________ stress
increased, lowered