Lecture 17. Cell Signalling in Development Flashcards
What is induction ?
Where one group of cells influences the development of a neighbouring group of cells
Who was induction first demonstrated by ?
Hans Spermann and Hilde Mangold
What is the important conclusion of the organiser experiment ?
Organiser cells from the donor could change the fate of the recipient cells and can set in motion a chain of events leading to the production of a new body plan
How can induction be achieved at the molecular level ?
By cells sending molecular signals to neighboring cells
What type of cell signaling is used to achieve induction at molecular level ?
Paracrine signalling
What is signal transduction ?
The mechanism that relays the signal received at the cell surface to the nucleus
What is the ultimate effect of cell signaling at the cell surface ?
A change in gene expression in the nucleus
What do cells need on their cell surfaces to respond in a particular way ?
A particular receptor
What happens as a result of only cells that possess a particular receptor on their surface can respond in a particular way ?
- Some cells will not respond at all to a signal if they dont have a receptor
- Two different cells can respond in different ways to the same signal (if they possess different receptors)
What is competence ?
The ability to respond to a signal
What is the ligand or signal of the TGF-beta pathway ?
BMP2
What is the receptors of the TGF-beta pathway ?
Tgfbr1
What is the transcription factor of the TGF-beta pathway ?
Smad
What are the roles in development in TGF-beta pathway ?
- Roles at all stages
2. Mesoderm induction
What is the signal in the Wnt signalling pathway ?
Wnt1
What is the receptor in the Wnt pathway ?
Frizzled/ B-catenin
What is the transcription factor in the Wnt signaling pathway ?
Tcf/Lef
What is some of the roles in the development of the Wnt pathway ?
- Roles at all stages
- Positional information at all regions
- Limb development
What is the signal in the Delta-notch pathway ?
Delta-like
What is the receptor in the delta-notch pathway ?
Notch
What is the transcription factor in the delta-notch pathway ?
Cst
What are the roles in development in the delta-notch pathway ?
- Roles at all stages
- Left-right asymmetry
- Neurogenesis
What is the signal in the Hedgehog signaling pathway ?
Sonic hedgehog
What is the receptor in the hedgehog pathway ?
Patched/smoothened
What is the transcription factor in the hedgehog pathway ?
Gli
What is the role in development in the hedgehog signaling pathway ?
- Positional information - neural tube and limb
What is the signal in the FGF pathway ?
FGF8
What is the receptor in the FGF pathway ?
Fgfr
What is the transcription factor in the FGF pathway ?
Not known
What are the roles in FGF pathway ?
- Roles at all stages
- AER of limb bud
- Gastrulation - maintaining mesoderm
What is the signal in the Hippo pathway ?
Stress
What is the receptor in the hippo pathway ?
Fat4 eg yap/taz
What is the transcription factor in the hippo pathway ?
Tead4
What is the roles of hippo in development ?
- Early mammalian
2. Kidney/skeletal