Lecture 15: Hypersensitivity Type II, III, and IV Reactions Flashcards
The Type II hypersensitivity reactions are allergic reactions involving tissue or
cellular antigens and antibodies of the ___ or ___ class.
IgM or IgG
True or False: Type II hypersensitivity may occur with or without the involvement
of complement activation
True
If a type II hypersensitivity reaction occurs WITH the involvement
of complement activation, the mechanism involves the complete _____ pathway and eventual ___ of the cell on which the
complement components are being deposited
classical complement pathway sequence and eventual lysis of the cell on which the
complement components are being deposited.
If a type II hypersensitivity reaction occurs WITHOUT the involvement of complement activation, _____ occurs and the cell is coated with __ or __ antibody or __. These
lead to phagocytosis and destruction of the cell by ___ or ____ or lysis
of the cell through ADCC and killer (K) cells.
antibody opsonization; IgG; IgM; C3b
neutrophils or macrophages
Transfusion reactions and Rh incompatibility reactions are examples of which type of hypersensitivity reaction?
Type 2
True or False: The ABO system contains naturally occurring antibodies
True
Human red blood cells have surface ___ antigens termed A and B. Type O is the absence of A and B. There are other minor
alloantigens, but these are the main ones.
glycolipid
The blood groups antigens are controlled by three alleles (_, _, and _). A and B are ____over O and ____with respect to
each other.
A, B, and O; dominant; co-dominant
True or False: In 80% of all humans, A and B alloantigens are also present as mucopolysaccharides in secretions such as saliva, sweat, etc.
True
Human serum contains naturally occurring IgM antibodies called
_______
isohemaglutinins (e.g anti-A, anti-B)
