Lecture 15

Question 1

Linkage Equilibrium

Answer 1

statistical independence of alleles at separate loci

Question 2

What can tell you there is linkage disequilibrium?

Answer 2

• loci are functionally connected (or metabolically linked)
• loci are physically close to each other on a chromosome (recombination is rare)
• all heterozygous pop

Question 3

What is disequilibrium a consequence of?

Answer 3

Admixture: evacuated island ex
tiny population reintroduced to a large (source) population

(Rare allele at one locus, it is more likely you have a rare allele in another locus)

Question 4

Statistical independence allows for use of what rule?

Answer 4

Product rule :P

Question 5

If population is in LE, what can you do if you’re given two genotype proportions?

Answer 5

You can multiply the genotype proportions to find the proportion of population with those two genotypes.

Question 6

Why is it important to know how rare a genotype is?

Answer 6

It strengthens the likelihood that the samples came from the same source if they match. / likelihood that it was not someone else

Question 7

What do you need to know?

Answer 7

• the relevant population
• the population genetic charactersitics (HWE and LE)

Question 8

What is RMP (Random match probability)

Answer 8

The probability that the genotype found is found in a random sample.
- the genotype proportion (across loci)

mult all exp hwe