Lecture 15 Flashcards

Parasites and Fungus

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1
Q

what is parasitism

A

living organism taking nourishment from host
lives on or in the host

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2
Q

ectoparasite

A

live on outer surface

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3
Q

endoparasite

A

lives inside the body

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4
Q

obligate parasite

A

requires host for all phases of life cycle

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5
Q

facultative parasite

A

can be free living, but can live in a host

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6
Q

accidental parasite

A

parasite finds the wrong host

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7
Q

erratic parasite

A

parasite that finds the wrong organ

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8
Q

definitive host

A

harbors the adult stage, or where there is sexual reproduction

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9
Q

intermediate host

A

has the larval stage or asexual reproduction

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10
Q

paratenic host

A

some other host, temporary

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11
Q

reservoir host

A

host is generally not greatly harmed by the parasite

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12
Q

protozoa

A

single cells with an organized structure
eat solids
need aquatic/moist environment
complicated life cycle
fecal-oral route of transmission
classified on locomotion: amoebae, flagellates, apicomplexa

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13
Q

protozoa schizogony

A

multiple rounds of mitosis without cytokinesis - creates a schizont
then cytokinesis occurs, releasing merozoites (daughter cells)

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14
Q

protozoa - amoebae

A

moves with pseudopodia
active growing phase - trophozoites
environmentally protected form - cysts

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15
Q

entamoeba histolytica

A

wide range of disease: diarrhea, dysentery, liver abscess, asymptomatic
fecal-oral transmission

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16
Q

entamoeba gingivalis

A

oral commensal

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17
Q

environmental amoebae

A

surface water
corneal infections with contact lens
cribriform plate
CNS infections

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18
Q

protozoa - flagellates

A

move with flagella
active growing phase - trophozoites
environmentally protected form - cysts
have a rigid outer wall - provides shape

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19
Q

giardia lamblia

A

wide range of disease: chronic diarrhea or asymptomatic
fecal-oral transmission

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20
Q

trichomonas vaginalis

A

vaginitis
sexual transmission

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21
Q

protozoa - apicomplexa

A

mature forms are non-motile
obligate intracellular parasites
complex life cycles
have a complex at the apical end

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22
Q

plasmodium spp

A

mosquito transmitted
malaria
life threatening

23
Q

toxoplasma gondii

A

mostly asymptomatic
can cause fetal malformations
can transmit from cat stool

24
Q

crytosporidium spp

A

watery diarrhea, can be chronic
fecal-oral or water borne

25
Q

helminths

A

worms
multicellular, macroscopic

26
Q

flatworms

A

flat on cross section
cestodes (Tapeworms)
trematodes (Flukes)

27
Q

roundworms

A

round on cross section
Nematodes
Hookworms
Pinworms

28
Q

cestodes - tapeworms

A

adult form: ribbon-like and segmented
abdominal discomfort

larval form: penetrates gut and lodges
intermediate hosts are humans

29
Q

nematodes - tapeworms

A

have a complete digestive tract and separate sexes
very diverse group

30
Q

A. Lumbricoides

A

abdominal pain/discomfort
transmits fecal-oral with ova in stool

31
Q

T. Spiralis

A

massive inflammation early
muscle damage later
transmits by eating undercooked meat

32
Q

ectoparasites

A

colonizes
insects - fleas, lice, bedbugs
arachnida - ticks, mites
nuisance, itchy
vectors for disease

33
Q

tick

A

borrelia burgdorferi
lyme disease

34
Q

fleas

A

yersinia pestis
bubonic plague

35
Q

humans eating fungus

A

bread, beer
Saccharomyces cerevisiae

soy sauce
Aspergillus oryzae

mushrooms and cheese

36
Q

fungus eating humans

A

can infect humans - mycosis or mycoses
superficial - skin, nails… Thrush, Ringworm
subcutaneous - traumatic implantation… tissue destruction and sinus
systemic mycoses - immunodeficiency, acquired through respiratory tract

37
Q

fungus

A

have a cell wall comprised of polysaccharides including chitin and chitosan

haploid cells mate to make diploid cells, undergo meiosis which produces four haploid spores

38
Q

yeast

A

single cells, elongate to form chain
pseudohyphae
reproduce by budding
blastospores

39
Q

molds

A

multicellular
tubular hyphae with or without separations
create specialized sporing structures

40
Q

dimorphic yeast

A

at lower/room temperature replicate as molds
at higher/body temperature replicate as yeasts
includes some pathogenic fungi with limited geographic distribution
spores can be infectious

41
Q

candida albicans

A

opportunistic pathogen
lack exotoxins or endotoxins
slow and chronic infections
thrush and yeast infections

42
Q

systemic candidasis virulent attributes

A

adhere to tissues and prostheses
change surface antigens
invade tissue with hyphae
produce enzymes that degrade host cells

43
Q

candida infections

A

thrush - oral, vaginal, perianal, esophageal

44
Q

pseudomembraneous candidasis

A

white membrane with raw, red base underneath

45
Q

erthematous candidasis

A

immunosuppression, antibiotic use or dentures

46
Q

angular stomatitis

A

lesions at angles of the mouth
erythema, soreness and fissuring
S. Aureus

47
Q

skin infections

A

candida infection
diaper rash or nails

48
Q

candida systemic infections

A

urinary tract - catheters
endocarditis - artificial heart valves of IV drug use
septicemia - with immunosuppression - throughout solid organs

49
Q

antifungals

A

major target is the fungal cell membrane
ergosterol vs cholesterol

50
Q

nystatin and amphotericin B

A

binds to ergosterol and creates a pore

51
Q

azoles

A

antifungal ex: fluconazole, clotrimazole, miconazole
inhibit synthesis by inhibiting enzyme required for ergosterol synthesis

52
Q

micafungin, anidulafungin

A

antifungals
inhibit glucan synthesis or specific gylcan in fungal cell wall

53
Q

keratolytic fungi

A

attack keratin - nail, hair, skin
produce keratinase
many different species

54
Q

dermophytes and dermatophytosis

A

fungal penetration balances squamous cell turnover long lasting
requires some minor trauma to establish
driven by moisture and occlusion
jock itch, athletes’ foot, ringworm
tinea cruris, tinea pedis, tinea corporis