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Microbiology 2 > Lecture 11 > Flashcards

Lecture 11 Flashcards

Intro Virology

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Biology 101 flashcards
1
Q

baltimore classification

A

viral genomes must make mRNA that can be read by host ribosomes

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2
Q

reverse complement

A

has to be coped into a positive strand to be read by a ribosome

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3
Q

non-enveloped viruses

A

very stable in the environment
minute mouse virus
coxsackievirus B4… poliovirus

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4
Q

enveloped viruses

A

fragile in the environment
influenza A virus
herpesvirus

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5
Q

how do bacteria divide

A

binary fission

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6
Q

how do viruses proliferate

A

by assembly

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7
Q

virus replication cycle

A

Attachment
Penetration
Uncoating
Transcription
Translation
Genome Replication
Assembly
Release

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8
Q

attachment is done through

A

viral attachment proteins (VAP)

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9
Q

what are viral attachment proteins (VAP)

A

viral proteins that bind receptors
glycoproteins (enveloped), fibers or canyons (non-enveloped)
can have multiple, redundant VAPs (Herpes)

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10
Q

how does attachment evolve

A

attachment is first weak, reversible electrostatic binding
attachment is strengthened by irreversible interactions (sometimes to a second receptor)

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11
Q

what prevents viral attachment

A

antibodies binding to VAPs

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12
Q

viral receptors vary _____

A

widely

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13
Q

permissive cell

A

allow for productive virus replication

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14
Q

resistant cell

A

does not express the virus receptor

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15
Q

penetration and uncoating

A

most viruses must escape endosomes before fusion with the lysosome, others fuse at the plasma membrane
nothing large diffuses fast in cytoplasm, virions require active transport on microtubules

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16
Q

penetration of a virus

A

a virus particle reaches the cytoplasm

17
Q

uncoating of a virus

A

a virus sheds its capsid

18
Q

the genome must be delivered to

A

the correct subcellular compartment

19
Q

enveloped virus entry

A

virions enter by endocytosis
acidification changes conformation of VAP
reveals a hydrophobic fusion peptide
fusion peptide penetrates host membrane
further conformational change fuses membranes

20
Q

influenza A VAP is

A

Haemagglutinin (HA)

21
Q

non-enveloped virus entry

A

makes a large hole in cell membrane
initial binding to CAR by adenovirus fiber
secondary binding to integrin
acidification in endosome degrades capsid
structural protein (Protein VI) penetrates endosomal membrane
membrane disruption allows remaining capsid to associate with microtubules and traffic nucleus

22
Q

example of non-enveloped virus

A

adenovirus

Microbiology 2 (18 decks)

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