Lecture 13 Flashcards
virions (what one) can also acquire envelopes from
anywhere in the secretory system
herpesvirus
virions must get past the
plasma membrane
new virions are created by
assembly of genomes and structural units
enveloped viruses must acquire
an envelope from a cellular membrane (budding)
non-enveloped viruses usually exit through
cellular lysis
early phase DNA virus macromolecular synthesis two types of gene expression
early and immediate early
immediate early genes
expressed without any viral gene expression
early genes
expressed early in infection before the genome replicates
often requires viral gene expression
DNA virus macromolecular synthesis
dsDNA
immediate early - Tc factors
early - TL
DNA replication (genome replication)
late proteins - Tc and TL
viruses have different strategies to
time late replication
early and late DNA virus macromolecular synthesis
early: subvert/take over the host cell, stimulate genome synthesis
late: assembly progeny virions, egress from the cells
early and late replication must avoid
the innate and adaptive immune responses
stimulation of the cell cycle
DNA synthesis occurs during S-phase
a DNA virus can stimulate S-phase or some DNA viruses encode their own DNA synthesis proteins
which viruses can stimulate S-phase
polyomavirus
adenovirus
papillomavirus
what virus encodes its own DNA synthesis proteins
herpesviridae
