Lecture 14-GPCR/G-protein signaling Flashcards
What is the stabilized trimer?
GDP
What does GDP signify?
no signal sent
What is the separated(no trimer) state?
GTP bound
What. does GTP signify?
signal transduced
What are the 3 parts of a GTPAse
ABY
What two steps is G protein+GTP inbetween?
receptor and adenylate cyclase
What type of molecule is cAMP?
second messenger
What happens when adenylyl cyclase is activated?
increase in cAMP
Trace the steps of adrenalin sequence
Adrenalin binds to beta-adrenergic receptor(activates GPCR)
G binds to GTP(separation)
Activation of adenylyl cyclase
cAMP made
Activation of PKA\
Reaction: increase heart rate, liver cells release glucose
What activates protein kinase a?
binding of cyclic AMP
How does protein kinase regulate other proteins?
by phosphorylation
What do phosphatase do?
remove phosphate
Why is glycogen broken down into glucose?
PKA phosphorylates
What is the purpose of termination?
turn off signals
What amplifies G proteins in the cytosol?
cAMP and PKA
