Lecture 13

Question 1

What is the vasa vasorum ?

Answer 1

A network of blood vessels that supply big blood vessels, since they’re so big.

Question 2

What is the clinical horizon?

Answer 2

The point up until which you show no symptoms of atherosclerosis.

Question 3

What can occur in the clinical phase of atherosclerosis ?

Answer 3

1. Thrombus and occlusion.
2. Aneurysm and rupture.
3. Stenosis.

Question 4

What is the fatty streak ?

Answer 4

The accumulation of a small layer of fat in the vessels. It is normal and everybody has it.

Question 5

What is atherosclerosis ?

Answer 5

The accumulation of a layer of fat in the vessels with fibrous tissue accumulation. It is abnormal and represents a pathological change in the vessel.

Question 6

What are the two key components of atherosclerosis risk factors ?

Answer 6

1. endothelial dysfunction.

2. chronic inflammation

Question 7

What is the pathogenesis of atherosclerosis ?

Answer 7

Hemodynamic stress ->Cell Mediators/Cytokines released -> Smooth Muscle Cell Proliferation -> Lipoprotein entry and accumulation -> Fibrosis of Smooth Muscle Cells