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Immuno Mem !! > Lecture 13 > Flashcards

Lecture 13 Flashcards

1
Q

Ag recognition by T cell induces?

A

IL12… proliferation differntation into effector or memroty

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2
Q

CD4 effector T cells

A

activate macrophages

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3
Q

signal 1

A

ag recognition

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4
Q

signal 2

A

costimulation

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5
Q

signal 3

A

cytokines

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6
Q

naïve T cells NEED

A

DCs

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7
Q

Effector T cells can use?

A

Mo and B cells

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8
Q

what are inhibitory molecules?

A

CLTA4 and CD45

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9
Q

Activating co stimulatory

A

CD44, CD43

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10
Q

superantigens bind?

A

simultandeously MHC class ii and the V reiogn of the beta subunit of the TCR
-not a peptides, bind to a specific region of TCR… glue
-massive amounts of cytokines produced, may lead to shock…
staphylococcal entertoxins

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11
Q

WHat help with costimulation of T cells?

A

B7

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12
Q

Activated APCs produce what? by cd28

A

IL12…. differentiate into effector cells, signal 3

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13
Q

cell survival cd28

A

Bcl-Xl, Bcl-2

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14
Q

cell proliferation cd28

A

IL2, cyclins up, cell cycle inhibitors down

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15
Q

CD28 binds to what?

A

b71 and b72 or cd80/86… or ICOSL

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16
Q

What is the coinhibitor of CD 28, they compete?

A

CTLA 4

17
Q

What else can CD 80 bind to?

A

PDL1… programed cell death, but 80 inhibits

18
Q

ICOS competes with CD 28 for?

A

ICOS L

19
Q

What induces expression of CD 40 on APCs?

A

Ag recognition

20
Q

CD40L binding will induce expression of?

A

B7 and the secretion of cytokines

21
Q

What reduces expression of S1PR1?

A

CD69, this causes cells to stay in LN and proliferate to effector and memory cells

22
Q

Expression is increased and enables activated T cells to respond to the growth promoting IL2

A

CD25, IL2Ralpha

23
Q

Expression of CD40L enables activated T cells too?

A

help macrophages and B cells… positive feed back mechanism to DCs for more proliferation

24
Q

CTLA4

A

regulates t cell response

25
Q

Co stimulatory T cells produce?

A

IL 4 , IL 5 and IFN gamma

26
Q

What induces anti apoptotic BCL 2

A

IL2

27
Q

stimulates cell cycles progression by inhibiting

A

p27

28
Q

If this is missing reg T cells will not develop

A

IL2

29
Q

T bet

A

drives differentiation twd development of effector cells in CD 4

30
Q

What promotes the gnereation of memory cells?

A

Blimp1

31
Q

WHat allows memory cells to not die and slowly reproduce?

A

IL7 and IL 15

32
Q

WHat are markers for T cells?

A

IL7R, CD45, CD27

33
Q

T cells express the chemokine receptor CCR7 and the L selectin for home maintain to Lns

A

central memory T Cell

34
Q

home to mucosal tissue

A

effector T cells… do not proliferate, but do produe cytokines IFN gamma or become cytotoxic

35
Q

IL 2 starvation triggers?

A

mitochondrial apoptosis

36
Q

death receptors

A

TNFRI and Fas

Immuno Mem !! (7 decks)

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