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Immuno Mem !! > Lect6 > Flashcards

Lect6 Flashcards

1
Q

What determines Ig type?

A

Heavy chain

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2
Q

What are the variety of heavy chains?

A

u, delta, gamma, epsilon and alpha

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3
Q

ImM has an extra?

A

constant region that is transmembrane bind to B cells

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4
Q

Papin breaks IgG into/

A

two Fab, one Fc

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5
Q

Pepsin breaks IgG into/

A

one bivalent, and peptide fragments

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6
Q

What six things are in the Ig superfamily?

A

IgG, TCR, MHC CLass I, CD4, CD28, ICAM1

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7
Q

What is the Ig super family for?

A

recognition, binding or adhesion

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8
Q

T cell Ag binding site

A

three cer V alpha, three CDRs V betas

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9
Q

Igs bind?

A

proteins, lipids, polysaccharides, small chemicals

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10
Q

Who disociates easier?

A

Ig

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11
Q

Ig rate?

A

rapid on, variable off

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12
Q

T cel rate?

A

slow on, slow off

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13
Q

What are CDR regions composed of?

A

two antiparallel beta strands, which form two beta pleated sheets held together by disulfide bonds

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14
Q

What creates a neoantigenic determinant?

A

proteolysis

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15
Q

Pre B cell production

A

cytoplamic u heavy, and pre B receptor

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16
Q

immature B cell

A

membrane IgM

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17
Q

matuer B cell

A

membrane IgM, IgD

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18
Q

Activated B cell

A

Low rate Ig secretion; heavy chain isotype switching; affinity maturation

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19
Q

antibody secreting cell

A

high rate Ig secretion; reduced membrane Ig

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20
Q

B cell changes from membrane to secreted

A

change from B cell receptor to effector fucntion

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21
Q

Isotype swithcing

A

each isotype serves a different set of effector functions

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22
Q

mucsoal secretions

A

IgA

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23
Q

plamsa

A

IgM

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24
Q

mast cells

A

IgE

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25
Q

tissue

A

IgG

26
Q

What has J chains/

A

A and M

27
Q

What has a scretory section

A

A

28
Q

150kDa

A

IgG

29
Q

vascular and extravascular

A

IgG

30
Q

most abundant immnoglobulin in blood

A

IgG

31
Q

bulk of immunity to most bloodborne pathogens

A

IgG

32
Q

Only Ab to cross placenta

A

IgG, passes humoral response

33
Q

IgG structure

A

two heavy gamma chains with either two kappa or two lambda light chaings

34
Q

IgG has four different subclasses

A

IgG1, IgG2, IgG3, IgG4

35
Q

What makes an IgG subclass different/

A

slightly different sequences in their H chains that result in differnt functions

36
Q

FCRn recruits?

A

IgG to fetal circulation eventually catabolizes

37
Q

present in external secretions

A

IgA

38
Q

420 kDa Dimer

A

IgA, in serum as 170kDa four polypeptide chain

39
Q

IgA structure

A

in addition to H alpha chain, the secreted have tow poly peptides… one J chain, one secretory, held together by disulfide bonds

40
Q

SC

A

is part of the poly Ig receptor involved in teh transepithelial transport of exocrin IgA an stabalizes IgA against proteolytic degrdation

41
Q

Iga is synthesized/

A

locally by plamsa cells in mammary and salivary glands, along respiratory, Gi and GU tract

42
Q

What is first line of defense against microbial invaders?

A

IgA

43
Q

First Ab produced by B cell

A

IgM

44
Q

BCR

A

IgM

45
Q

IgM expresses what on B cell

A

two u H chains and two L chains

46
Q

Blood IgM

A

fiver four chain units held together by disulfide bridges

47
Q

What dose J chain do?

A

initiates polymerization of the subunits during secretion from a plasma cell

48
Q

900 kDa

A

IGm

49
Q

found primarily in bloodstreem

A

IgM, high affinity, effective in removing microbes

50
Q

Low quntities

A

IgD

51
Q

Ag recetor B lymphocyte primary function

A

IgD

52
Q

B cells express ?

A

IgM and D

53
Q

What Ag interactis with IgMandB on B cell it is?

A

internalized, processed and presented to T helper cells

54
Q

very low levels, acute inflammation, infection oby worms and allergic reactions

A

IgE

55
Q

binds to mast cells

A

IgE

56
Q

What happens when Ag binds to IgE on mast cell?

A

releases triggers relase of mediators

57
Q

alpha

A

IgA

58
Q

gamma

A

IgG

59
Q

u

A

IgM

60
Q

e

A

IgE

61
Q

delta

A

IgD

Immuno Mem !! (7 decks)

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