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Immuno Mem !! > Lecture 11 > Flashcards

Lecture 11 Flashcards

1
Q

HSCS give rise to

A

common lymphoid progenitors

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2
Q

CLPs give rise to

A

Nk, B and T

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3
Q

Pro B cells turn into

A

follicular B cells, marginal zone B cells, B1cells

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4
Q

Pro T cells turn inot

A

alpha beta T cells

lambda delta T cells

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5
Q

Ig heavy chain locus opens up

A

developing B cells

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6
Q

alpha beta T cells

A

TCR beta gene lucs open

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7
Q

Who commit to T cell transcrition

A

Notch 1 and GATA 3

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8
Q

Notch activated by being

A

cleaved

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9
Q

enduce B cell development

A

EBF, E2A, Pax-5

  • Rag1 and 2 BCR rearrangment
  • surrogate light chins
  • the Igalpha dn beta BCR
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10
Q

Cytokines stimulate

A

proliferation

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11
Q

produced by stromal cells in thymus drives proliferation of T cell

A

IL7

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12
Q

mutation of gamma chain causes IL2,7,15 to block

A

cause T cell and NK resulting in immunodeficiency

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13
Q

required for NK development

A

IL15

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14
Q

DNA methylation

A

silences genes

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15
Q

miRNA

A

silence genes

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16
Q

modifictioan of histone tails

A

activate or inactivate

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17
Q

can enhance or suppress gene expression

A

remodeling complex

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18
Q

CD4 vs 8

A

CD4 is suppressed by chromatin modification for CD8 to display

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19
Q

miRNA modulate?

A

T cell during development

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20
Q

a key enzyme in miRna

A

dicer

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21
Q

What causes lause of reg T cells?

A

deletion of dicer

22
Q

loss of Dicer in B cell lineage

A

block at pro B cell pre B cell transition

23
Q

-miR17-92 plays a key role in?

A

apoptosis of pre B cells inhibiting Bim

24
Q

miR150 targets ?

A

a notch receptor that palys improtnat roles in proliferation differentiation and survival of T cells

25
Q
  • restriction to VlCl or VhCh

- governs expression of TCR

A

allelic exclusion

26
Q

3 mechanism for rearrangment

A
  • somatic recomitnation
  • mRNA splicing
  • junctional diveristy
27
Q

expression of BCR and TCR initiated by?

A

somatic recombination

28
Q

epitope specific diversity caused by?

A

DNA chromosomal rearrangment

29
Q

activating gene 1 and 2 encode enzymes performing recombination of BCR and TCR during VDJ recombintioatn

A

RAG 1 and 2

30
Q

RAG1 and RAG

A

restricted to B and T lymphocytes during developmental stages

31
Q

H chains have how many segments/

A

4 V, D, J, C

32
Q

BCR diversity first

A

D and J chosen, DNA btw them deleted

33
Q

Second in BCR

A

J chosen, VDJ btw deleted. C

34
Q

Vh produced?

A

first… once it is good, goes onto produce Vl

35
Q

second test

A

rearrangement for Vl

36
Q

VDJ recombination success brings?

A

promoter sequence closer…. transcrtipion occurs

37
Q

JC lie downstream of the rearrandged VDJ exon sepreated by intron

A

form RNA transcript

38
Q

splicing out of exons allows

A

mRNA that can be translated on ribosome to produce antigen receptor

39
Q

kL chain is made up of

A

35X B
5X J
1X C

40
Q

lambda L

A

30X B
1XJ
4XC

41
Q

generated at the pts btw the joining gene

A

junctional diversity

42
Q

Juctional diversity results from?

A

loss of nucleotides thr action of exonucleases and from the addition of N and P nucleotides

43
Q

P

A

hairpin loops, can be incorporated in or removed

44
Q

What cleaved DNA hairpin and adds P nucleotides?

A

RAG

45
Q

addition of N nucleotides aided by?

A

TdT

46
Q

first check point

A

after first polypeptide chains of the two chaing Ag receptor is completed

47
Q

checkpoint 2

A

second polypeptide chain of Ag is completed

48
Q

checkpoints

A

ensure only those who have successful rearrangement, and eliminate potentially harmful self reactive lyphocytes

49
Q

Pre B and T

A

Pre B= u

Pre T= beta

50
Q

exibit what to continue going on/>

A

survival signals, or undergo apoptosis

51
Q

If second poly peptide is bad. what happens to T? B

A

T=apoptosis

B=rearrangment

52
Q

clonal deletion

A

getting rid of self recognizing, important mechanism for central tolderance

Immuno Mem !! (7 decks)

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