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Immuno Mem !! > Lect8 > Flashcards

Lect8 Flashcards

1
Q

CD4… attach to non variant portion of MHC

A

T helper cells

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2
Q

CD8…attach to non variant protion of MHC

A

cytotoxic T cells

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3
Q

Cytotoxic T cells

A

MHC class I

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4
Q

T helper cells

A

MHC class II

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5
Q

MHC class II are expressed on?

A

dendritic cells, Mo, and B cells… APCs

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6
Q

MHC I are expressed on?

A

all nucleated cells

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7
Q

T cell activation leads to?

A

IL2… which controls clonal expansion

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8
Q

TH1

A

help Mo get rd of intracellular organisms. activate ctyotoxi T cells

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9
Q

TH2

A

mainly involved in helping B cells develop memeroy cells

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10
Q

Th2 cells important for B cell proliferation

A

IL-4

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11
Q

TCR composed of?

A

two polypeptide alpha beta make up C and V

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12
Q

rare TCR

A

gamma and delta- broader specificity to include HSPs and phospholipids

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13
Q

genes coding for TCR polypeptide chains

A

members of the Ig super family

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14
Q

part of TCR complex

A

CD3

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15
Q

what is CD3 made up of?

A

gamma, delta, epsilon

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16
Q

two separate signaling molecules for TCR

A

zeta zeta

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17
Q

Class I genes encode a polymorphic heavy chain… expressed on surface of all nucleated cells.

A

HLA-A, B , C… combines beta2, microglobulin

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18
Q

Class II genes encode?

A

HLA DP, DR, D, DQ. composed of two dissimilar polymorphic polypeptide chains, alpha and beta, which contribute to peptide binding grooove

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19
Q

WHat is the binding site for MHC I and II

A

polymorphic region

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20
Q

class one made up of?

A

polymorphic alpha and beta 2 macroglobulin

-alpha chain is glycosalated

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21
Q

Class II composed of?

A

polypeptide alpha and beta… both are glycosolated

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22
Q

anchor residues are on?

A

the peptides

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23
Q

anchor residues bind to?

A

residues in the class I and II grooves and vary for MHC alleles

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24
Q

Which can hold longer peptides?

A

class II because it is open

25
Q

Expression of MHC is modulated by?

A

cytokines

26
Q

WHat binds to MHC I?

A

viruses that have infected the cell.. endogenous pathway

27
Q

MHC II recognize?

A

pathogens taken from the environment

28
Q

clonal expansion and differentiation into effector T cells

A

Naïve T cell activation

29
Q

macrophage activation cell mediated immunity

A

effect T cell response

30
Q

B cell activation and antibody production humoral immunity

A

Effector T cell response

31
Q

What increases expression of MHC II on ddendritic cells?

A

IFN gamma

32
Q

Costimulatiors of dendritic cells and macrophages

A

TLR ligands. IFN gamma, T cells CD40, CD 40L

33
Q

Principal functions of dendritic cells

A

initiation of T cell resposnes to proteins

34
Q

macrophages induced MHC II expression by?

A

IFN gamma

35
Q

B lymphocyte class II MHC expression increased by?

A

IL 4

36
Q

Costimulatiors of B lyphocytes

A

induced T cell antigen receptor cross linking

37
Q

Principal function of B lymphocytes

A

antigen presentation to CD4+ helper T cells in humoral immune responses

38
Q

Activated dendritic cells express high levels of?

A

B7, ICAM-1, IL 12

39
Q

NK cells produce what during innate immune reactions to microbes or by T cells during adaptive immune response?

A

IFN gamma

40
Q

IFN gamma stimulates?

A

class II MHC and CD4

41
Q

what effects experession of class I MHC and activation of CD8

A

IFN gamma and type I interferons

42
Q

recognize cell associated and NOT soluble Ag

A

alpha beta T cells

43
Q

extra cellular Ag recognition

A

CD4

44
Q

intracellular Ag recognition

A

CD8

45
Q

Virus that is in cytoplasm and synthesized,

A

goes to proteosomes

46
Q

Peptides goes to ?

A

ER where it assembles peptide class I complex.. is taken to surface

47
Q

editing mechanism works to ensure the presentation of only the protein fragments most relevant for elcicinting an immune repsone

A

HLA DM

48
Q

What causes the dissociation of CLIP?

A

DM from the peptide biding groove of MHC II

49
Q

what stabilizes and prevents degradation of the empty MHC II

A

HLA DM

50
Q

facidliates the binding of antigen fragments to the open stabilized bidining groove

A

HLA DM

51
Q

WHere is MHC II synthesized

A

ER

52
Q

CLIP stays on MHC II until

A

peptide binds and goes to surface to be expressed

53
Q

MHC I peptides are produced from

A

cytoplasmic proteosomes

54
Q

MHC II peptes come from?

A

endosomal and lysosomal protsases

55
Q

site of MHC I peptide loading

A

ER

56
Q

site of MHC II peptide loading

A

specialized vesicles

57
Q

molecules involved in transport of peptides and loading of mHC moleduels class II

A

invariant chain and DM

58
Q

Class I loading moleduls

A

TAP

Immuno Mem !! (7 decks)

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