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Immuno Mem !! > Lect 9 > Flashcards

Lect 9 Flashcards

1
Q

Primary T cell deficiency

A 
CD 40 ligand
CD 40
CD 3 gamma
CD8
ZAP 70
CA channel
CD 25
STAT 5B
ITK
DOCK8
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2
Q

signal transduction extracellular domain recognizes?

A

soluble ligands

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3
Q

nuclear receptors intracellular transcription factors recognize?

A

lipid soluble ligands that cross plasma membrane

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4
Q

clustering of receptors

A

cross linking

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5
Q

initiates signal transduction

A

phosphorylation of tyr, ser, thre

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6
Q

phosphatses

A

play inhibitory role

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7
Q

alternative signal tranduction

A
  • addition of ubiquitin molecules
  • addition of lipids
  • acetylation and metyhation of N tail of histones… modulate gene expression
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8
Q

non receptor tyr kinase based receptor

A

integrin Src kinases

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9
Q

EGF insulin

A

tyrosine kinase receptor

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10
Q

Vitamin D glucocorticoids

A

goes to nucleus for transcrtiption of hormone gene

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11
Q

chemokines prostglandins

A

GPCR ligand… beta sheet transmembrane protein

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12
Q

delta delta like notch ligands

A

transcritipn of notch target gene

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13
Q

Src family

A

c-src, lyn, fyn, lck

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14
Q

Syk family

A

zap 70, syk SH2

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15
Q

tec family

A

tec, btk, and Itk PH

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16
Q

bind phosphotyrosing containing peptides

A

SH2

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17
Q

recognize proline rich stretches in polypeptides

A

SH3

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18
Q

PIP3 or other lipids

A

PH

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19
Q

adaptor protiens

A

promote the assembly of complexes… often contain proline rich stetches that can bind SH3… may contain tyrosines for SH2

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20
Q

LAT

A

linker for the acitavtiaon of T cells, integral membrane protein shtat functions as adaptor

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21
Q

BLNK

A

B cells Linker

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22
Q

CADS and SLP 76

A

two cytosolic adaptors

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23
Q

LAT gets phosphorylated and recirites?

A

PH C and the GADS adaptor

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24
Q

SLP76 what domain?

A

SH3, associated with GADS and recurits VAV, which is a tyrosine phosphorlated

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25
Q

VAV

A

actin cytoskeletal rearrangmetn

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26
Q

PLC gamma binds to?

A

SH2

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27
Q

PLC gamma activates

A

Ca signaling

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28
Q

inhibitory signal found on B cells and myeloid cells

A

FC gamma RII B

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29
Q

Ag binding and clustering results in?

A

Src family activation for TCR and BCR

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30
Q

SRC family does what?

A

phospholates ITAM

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31
Q

SYK recognize

A

phosphorylated tyrosine and have tandem SH2 domain.. and can bind ITAM

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32
Q

TCR complex made up of?

A

6X ginaling chains and 10X ITAMs

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33
Q

ITAMs interpret

A

affinity

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34
Q

Weak TCR signal

A

positive slection f T cells in the thymus

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35
Q

strong TCR signals

A

apoptosis

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36
Q

What is co receptor on B cells

A

complement receptor type 2 (CR2/CD21)

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37
Q

inhibitory T cell receptor

A

CTLA 4

38
Q

inhibitory receptors in B

A

CD 22 and Fc gamma RIIB

39
Q

costimulation in activation of T cells

A

CD 28 and CD80/86

40
Q

APC CD80/86

A

naïve T cell CD 28 Th cell activation

41
Q

TCR without presence of costimulation

A

MHC class II in absence of co receptors induces cell death or anergy

42
Q

CD40L

A

CD40 T cell activation w/ TCR and CD28

43
Q

TCR associated signaling molecules

A

CD3 and zeta non covalently linked to TCR

-mediated by charges residues in their transmmbrane regions

44
Q

IG associated signaling molecues

A

Ig alpha and beta

45
Q

Th signal transduction

A

CD4

46
Q

cytotoxic signal transduction

A

CD8

47
Q

Th antigen recognition

A

TCR

48
Q

SIgnal transduction for Th

A

CD3, CD 28.. link via B7-1/B7-2 on APC

49
Q

Th adhision

A

LFA-1…. via ICAM on APC

50
Q

When does CD 4 appear

A

antigen presenting MCH II

51
Q

WHen does CD 8 appear?

A

MHC class I from all nucleated cells

52
Q

CD28 signal transduction

A

ligand B7-1.B7-2 on antigetn preseing cells

53
Q

CTLA 4 negative regualation signal transduction

A

ligand B7-1/B7-2 on antigen presenting cells

54
Q

PD1 negative regulation signal trnasduction

A

PDL1/PDL2 antigen presenting cell, tissue cells, tumor cells

55
Q

LFA for adhesion

A

ligand ICAM1 from antigen presning cells or epithelium

56
Q

CD8 is composed of?

A

two related chains, CD8 alpha and beta

57
Q

CD4 is composed of?

A

four extracellular Ig like domains, a hydrophobic transmembrane region, and a highly basic cytoplasmic tail 38aa long

58
Q

CD 4 Binds to TCR

A

causing Lck and ZAP 70

59
Q

ZAP 70with CD4 causes

A

phosphorylation of LAT and SLP 76

60
Q

Cd4 associated Lck becomes activated?

A

CD3 and zeta chains

61
Q

what binds to zeta?

A

ZAP 70

62
Q

ZAP 70 activates

A

LAT

63
Q

Lat becomes docking site for?

A

PLC gamma 1

64
Q

PLC gamma 1 activates

A

RAS and MAP kinases

65
Q

activated PI3 brings?

A

PIP3 from PIP2

66
Q

PDK1 binds to

A

PIP3

67
Q

PDK1 activates

A

Akt to cause cell survival by inactivating Bcl-2

68
Q

PKC theta associateds with

A

TCR intracellularly

69
Q

Lck activates?

A

ZAP 70 upon Ag recognition

70
Q

ZAP 70 phosphorlates

A

LAT

71
Q

LAT binds

A

Grb 2 adaptor

72
Q

Grb2 docks/

A

GTP/GDP exchange factor SOS

73
Q

SOS converts

A

RAS GDP to RAS GTP

74
Q

RAS GTP activates

A

MAP kinase and ERK… which activates AP1

75
Q

actaveated LAT binds

A

PLC gamma 1

76
Q

LAT was activated by?

A

ZAP 70

77
Q

PLC gamma 1 hydorlyzes membrane

A

PIP2 to gnereate IP3 and DAG

78
Q

IP3 stimulates

A

increase in cytosolic Ca relased from ER

79
Q

DAG activates

A

PKC

80
Q

PCK and Ca induce

A

numerous other cellular responses

81
Q

Ag stimulate T cells transactivated?

A

IL2 gene

82
Q

PKC is important for?

A

NF kappa B

83
Q

NF kappa B is?

A

p50p60 heterodimer incatevated by Ikappa B

84
Q

PKC phosphorylates

A

IkB and activated NF kappa B is translocated into thenucleus

85
Q

AP1 and NFkB regulate?

A

gene expression

86
Q

NFAT alone elcits?

A

expression of a distinct set of anergy inducing genes

87
Q

production of anergy genes?

A

inhibit T cell function at different levels and induce a status of T cell unresponsiveness

88
Q

TCR signal 1 and CD28 signal 2 induce

A

different singaling pathways that result in the activation of several transctiption factors

89
Q

NFAT cooperates with ?

A

AP1 and NFkB to induce gene expression of prouctive immune response

90
Q

TCR singal 1 occurs

A

in the absence of co stimulation ca mediated signals iduce that acitavtes of NFAT only

Immuno Mem !! (7 decks)

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