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Immuno Mem !! > Lecture 12 > Flashcards

Lecture 12 Flashcards

1
Q

Before birth B cells precursors commit in?

A

liver, after in bone marrow

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2
Q

mature further in

A

spleen, when expressing IgM

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3
Q

follicular B cells express?

A

IgM and IgD, populated all peripheral lymphoid organs

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4
Q

earliest cell commited to B

A

pro B, no Ig

-Rag1 and 2 first expressed later for Heavy chains

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5
Q

TDT most abundant

A

on pro B stage When VDJ recombination occurs at Ig H locus

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6
Q

cecreases befreo L chain gene VJ recombination is complete

A

TdT

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7
Q

most abundant in H chain

A

junctional diversity

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8
Q

primary transcript occurs

A

undergoes splicing introns are removed exons joined.

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9
Q

pre BCR composed of

A

u IgH.. invariant surrogate IgL

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10
Q

surrogan IgL

A

V pre B protein and lambda 5 protein… turn into k and lambda chain

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11
Q

covalently attached to the u IgH chaing by disulfide bond

A

lambda5

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12
Q

What singls show up as n B mature B cells

A

alpha and beta signal transudcers

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13
Q

rearrangment of IgH locus

A

at the pro B cell stage… gives rise to u Ig chain if successful

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14
Q

first check point for B cells

A

expression of pre BCR

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15
Q

downstream signal responsible for proliferation survival and maturation of pre BCR

A

BTK bruton’s tyrosine kinase

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16
Q

mutation in BTK

A

agammaglobulineamia XLA… falure of b cell maturation

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17
Q

light chain isotope exclusion

A

only one type can present

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18
Q

BCR provides Ag independent toxic signals that?

A

shuttoff the RAG gene expression that prevent further Ig rearrangment

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19
Q

most B cells from fetal liver or stem cell become

A

B1

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20
Q

bone marrow precursors after brith give rise to

A

B2

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21
Q

B1 cells have?

A

Igm, CD5,

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22
Q

folicular B2 cells have

A

Igm and IgD recirculating lymphocytes

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23
Q

Marnial zone B cells have

A

Igm and CD/21/CR2, abundant in sleepn and Lns

24
Q

B1 B’s are

A

self renewing, produce natural Abs involved in self defense

25
Q

folicular B2 cells are the only ones to??

A

devlop into long lived plasma cells or memory B cells

-must be replenished in bone marrow

26
Q

MZ B cells

A

repsond to blood borne ags

27
Q

MZ B’s are?:

A

independent of T helper cells

28
Q

MZ and B1

A

self renewing

29
Q

B1B pleural and peritoneal cavites

A

most of serum IgM in early phases of infection

30
Q

what is not expressed in fetal liver?

A

TdT, causing limmited BCR diversity in B1 cells

31
Q

B1 sponateoulsy secrete IgM for?

A

microbial polysacchariedes and lipids and oxidized lipids

-natural antibodies

32
Q

How are follicular B cells expressed?

A

long primary RNA then, alternative RNA splicing

33
Q

MZ B cells

A

Marginal sinus of sleen

-respond to polysaccharid Ags and genreate natural Abs

34
Q

MZ B cells turn into

A

short lived IgM secreting plamsa cell. dealing with blood borne microbes

35
Q

thymic environment

A

required for proliferiation and matruation of thymocytes

36
Q

DiGeorge snydrome

A

immulogic deficency associated with lack of thymus

37
Q

developing T cells in the thymus

A

thymocytes- mostly occurs in the cortex… then enter medulla and exit the thymus through circultion

38
Q

cortical epithelial cells

A

essential for meshwork of thymocytes maturation

39
Q

epithelia cells in medulla

A

role of APCs for negative selection

40
Q

macrophages present in what of thymus

A

medulla

41
Q

What causes entry to thymus

A

CCL25 recognizes CCR9 on precursors

42
Q

CCL21 and CCL19 recognized?

A

thymocytes via CCR7 and guide movement from cortext to medulla

43
Q

proliferation of thymocyes

A

IL7

44
Q

cortical thymocytes do not express?

A

TCR CD3, zeta chains, cd4 or cd 8

-these are considered to be double negative state and pro T

45
Q

Rag 1 and 2 are first expressed in ?

A

double negative stage

46
Q

The Dj rearrangement of what is first?

A

the beta locus

47
Q

VDJ rearrangement occurs in what stage?

A

pro– pre t

48
Q

What controls TCR alpha signal recombination

A

a second wave of rag

49
Q

What are the only cells that mediate positive slection of TCR and how?

A

by displaying slef peptides bound to I and ii mhc molecules … cortical epithelial cells

50
Q

go from double positive to single positive

A

depends on what mhc class they recognize as to if they become cd4 or cd8

51
Q

what activate Runx3 that maintain CD8 T cell phenotype?

A

weak signals

52
Q

What causes CD4 fate?

A

GATA 3

53
Q

What is the proapoptotic protein?

A

BIM that plays a cruicial role in the induction of mitochondrial leakiness Ca and apoptosis

54
Q

DC and Mo in the medulla?

A

are APCs that mediate negative selection

55
Q

regulatory T cells

A

develop from high affitity to self and act as autoimmune reactions

56
Q

lambda beta cells are?

A

limited

Immuno Mem !! (7 decks)

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