Lecture 12

Question 1

What does MALT stand for?

Answer 1

Mucous Associated Lymphoid Tissue

Question 2

What does GALT stand for?

Answer 2

Gut Associated Lymphod tissue

Question 3

What does BALT stand for?

Answer 3

Bronchi Associated Lymphoid Tissue

Question 4

What are the specialized organs of MALT?

Answer 4

Waldeyer’s ring, Peyer´s patches, Appendix

Question 5

Antigenic stimulation in one part of MALT leads to _____________ also in other compartments of MALT.

Answer 5

immune response

Question 6

Directed migration is regulated by ___________ of __________ molecules called ____________ on lymphocytes.
Tissue specific endothelial ligands are called __________.

Answer 6

selective expression; adhesion; homing receptors; addressins

Question 7

What are high endothelial venules?

Answer 7

Specialized venules. The site where lymphocytes leave the blood stream and migrate into lymph nodes, spleen, organs of MALT.

Question 8

M-cells are specialized _____________ responsible for transport of ________ from the gut towards the ___________ cells inside the Payer´s patches.
Transport in mediated by ____________.

Answer 8

enterocytes; antigens; immunocompetent; transcytosis

Question 9

Stimulation of the GALT frequently leads to induction of immune __________ to the stimulating _________.
This occurs mainly if the gut is in normal, _____________ conditions.
Induction of ___ cell is the main mechanism.

Answer 9

antigen; tolerance

non-inflammatory

Th3

Question 10

What are the mucosal associated Lymphatic tissues?

Answer 10

Immune tissues of the urinary tract, genital tract, conjunctiva, middle ear, and breast gland.

Question 11

What is IgA?

Answer 11

A predominant immunoglobulin secreted through the epithelial cells.

Question 12

What are homing of lymphocytes?
Regulated by?

Answer 12

The directed migration of subsets of circulating lymphocytes into particular tissue sites.
Regulated by selective expression of adhesion molecules called homing receptors on lymphocytes.

Question 13

What are M cells?

Answer 13

Specialized enterocytes responsible for transport of antigens from the gut towards the immunocompetent cells inside the Payer´s patches.

Question 14

Why is tolerance important?

Answer 14

To avoid unnecessary reactions to non-pathogenic antigens.

Question 15

Homing lymphocytes: What are adressins?

Answer 15

Tissue specific endothelial ligands.