Lecture 11: Female Reproductive System Flashcards
Majority of female reproductive system is…
Duct system
The ovaries are homologous to the…
testes
In an adult female, ovaries are the size and shape of…
almonds
How much does each ovary weight?
3 grams each
Ovaries are posterior to the
uterus
It’s important that ovaries are kept in position relevant to fallopian tubes. Fallopian tubes don’t touch ovaries. If ovaries move around, what happens?
We increase likelihood that eggs that are being ovulated don’t make it into fallopian tube.
What are the structures that keep them in place?
- Ovarian ligament
- Mesovarian ligament
- Suspensory ligament
What does the Ovarian ligament do?
Connects ovary to uterus. Helps to keep it in place
What does the Mesovarian ligament do?
helps keep the ovary in the right place
Last is the Suspensory ligament ?
the retractor doesn’t keep the ovary in the right place
(3:14)
The Mesovarian is carrying…
blood vessels, lymphatics, and nerves.
The vaginal canal is open…
to the outside world.
The cervix is open to the…
vaginal canal
The uterus is open to the …
cervix
The fallopian tubes are open to the
uterus
There’s open space in the abdominal pelvic cavity, between the fallopian tube and the ovary. This can present a problem bc…
if a woman gets a vaginal infection and it’s not treated, it can progress up into the uterus, into fallopian tubes and ultimately into the abdominal pelvic cavity.
The other reason that there’s an issue here that we need to pay attention is even with all these ligaments, helping to hold the ovaries in the right position, relative to the fallopian tube, …
it is still possible that an egg can be ovulated and not go into the fallopian tube. And bc is open, sperm can also go out into the fallopian tube
If that egg that’s not in the fallopian tube meets up with sperm that’s not in the fallopian tube, …
you can’t have fertilization outside the reproductive system and that fertilized egg can plant in the wall of the abdomen and plant in all sorts of places it shouldn’t be.
This is called
ectopic pregnancy
Ectopic pregnancy is never going to reach term because…
there is no way for a placenta to develop.
But depending on where that egg implants, it can be
life threatening
Males can make more spermatogonia as they go through mitosis and meisosis. Females can’t make more stem cells. In females, their stem cells are called…
Oogonia.
What that means is, while a man can continue to make sperm, for the vas majority of their adult life, women…
are born with all the eggs they’re gonna have.
Medically, this makes a big difference. Ex: You have a male patient who has to go thru chemotherapy. That might affect their fertility level for a while but they will resume making sperm at the level of a healthy male once the effects of the chemotherapy has past. Women who go thru chemotherapy, …
harvest eggs if they’re at child bearing years.
B4 they go thru chemotherapy bc they’re not able to make more oogonia, …
if those cells get killed off by chemotherapy, we now have a woman who can now not have children.
So, we start with an oogonium and gonna watch this now. Just like we had in a male, we have mitosis and we’re gonna go into meiosis 1. So, first division looks just like …
mitosis
What we’re gonna get is one large cell and one small cell. The small cell is called
a polar body
It gets just enough membrane and cytoplasm to hold the DNA that we’re not gonna use. The large cell, secondary oocyte, …
most of the cytoplasm & organelles are in the secondary oocyte.
As we go thru meiosis to make an egg, what we’re gonna wind up with at the end is …
one functional egg and 2 or 3 polar bodies.
The reason is the egg is gonna supply the organelles, nutrition, energy is
to keep a newly formed embryo alive until you can get implantation
So, we don’t evenly divide the resources. Meiosis 1 gets us
our first polar body and secondary oocyte.
Meiosis 2, might divide, might not. Our secondary oocyte is going to…
divide and give us a mature egg and a second polar body.
If everything divides, we wind up with…
one mature oocyte and 3 polar bodies.
The second division in meiosis for an egg is triggered by …
fertilization.
Meiosis 1 starts in utero. Then, it gets suspended until puberty. At puberty, what’s gonna start happening is…
you’re gonna have groups of these oocytes start to complete meiosis and start to develop as follicles.
The idea is that ultimately, the one developing most quickly, is going to be…
the egg that’s going to be released in ovulation.
The rest of them will be delayed. While there’s a chance that the ovulated egg can get fertilized, we’re gonna…
stop meiosis
What you need to remember about the female reproductive system is that…
it’s built to save all the resources for pregnancy.
So, in a few days leading up to ovulation till we know it’s not possible for the woman to be pregnant, we …
turn down everything else and focus on those actions of hormones, follicles, etc that would support pregnancy.
Ovaries have 2 layers. We have the outer portion called…
cortex
The portion is in the middle is the…
medulla.
Outside here, we have a an outermost layer called…
germinal epithelium
The germinal epithelium is…
part of a capsule that surrounds the ovary.
Deep to that, we have a layer called…
tunica albuginea.
Throughout the coretx of the ovary, we have eggs and follicles that are in different levels of development. So, in the smaller structure, these are oogonia that haven’t started dividing and allowing cells to develop. What happens here is…
that we’re gonna have our egg.
As development starts, we’re gonna put a single layer of cells around this. These cells are…
called granulosa cells.
The layer of granulosa cells that’s touching the egg, is…
going to leave with the egg when it gets ovulated.
Once the egg gets ovulated, we’re gonna change the name of these particular cells. Now, we only have a single layer of granulosa cells, this is…
a primary follicle
As development continues, we add layers of granulosa cells . When we get enough layers of granulosa cells, some of the outer layers are going to change and we’re gonna get …
a layer or two of theca interna cells.
Outside that, we’re gonna get a layer of theca externa cells. The theca externa cells…
make up fibrous capsule around this particular follicle.
The theca interna cells make…
testosterone.
That testosterone is taken up by…
granulosa cells.
That granulosa cells converts…
testosterone into estrogen.
For the female reproductive system, the main role of testosterone is…
to be a precursor for estrogen.
As the follicle continues to develop, we get a space called the…
antrum
The antrum is filled with…
fluid, primarily, estrogen-riched fluid.
That first layer of granulosa cells that is touching the egg and travels with the egg when it’s ovulated, once the egg is ovulated, those cells are called…
cumulus cells.