Lecture 11: Endocrine Disruptors

Question 1

Name the 5 non classical endocrine glands

Answer 1

1) Brain
2) Kidney
3) Heart
4) Liver
5) GI

Question 2

What hormones does the kidney produce?

Answer 2

renin (in the JGA)

erythropoietin

Question 3

What does renin do?

Answer 3

reads blood volume to control arteriolar diameter (cleaves angiotensinogen to ATI – precursor to ATII)

Question 4

What does erythropoietin do?

Answer 4

stimulates proerythroblasts and differentiation of RBCs

Question 5

What is doping and why is it bad?

Answer 5

take recombinant EPO to increase hematocrit - can lead to hypertension and encephalopathy

Question 6

What hormones are produced by the heart?

Answer 6

ANP and BNP

Question 7

What do ANP and BNP do?

Answer 7

1) decrease vascular smooth muscle tone
2) decrease peripheral vascular resistance
3) increase capillary permeability

GENERATES INCREASE IN HEMATOCRIT

Question 8

ANP responds to ______________ while BNP responds to ________

Answer 8

blood volume; stretch

Question 9

How do ANP and BNP increase filtration rate/decrease blood volume?

Answer 9

decrease afferent arterial tone and increase efferent tone

Question 10

Between ANP and BNP, which is the better diagnostic tool and why?

Answer 10

BNP (longer half life)

diagnostic for congestive heart failure

Question 11

What are some environmental endocrine disruptors?

Answer 11

1) PCBs (polychlorinated biphenyls)

2) DES (diethystilbestrol)

Question 12

What do PCBs do?

Answer 12

compete with thyroid hormone binding to its transporter in the blood (TTR, TBG)

increases breakdown of thyroid hormone, body thinks it is hypothyroid so it makes more and develops a goiter

Question 13

What is DES?

Answer 13

synthetic estrogen