Lecture 1

Question 1

Blood producing stem cells are called

Answer 1

Haematopoietic stem cells

Question 2

What type of cell in the Bone Marrow derives all Adaptive Immune cells?

Answer 2

Early Lymphoid Progenitor

Question 3

Which surface bound immunoglobulin recognises Antigens?

Answer 3

B - Cell antigen receptor

Question 4

What is Clonal expansion?

Answer 4

The proliferation of stimulated B - Cells

Question 5

B - Cells are ______ unless stimulated to respond

Answer 5

B - Cells are quiescent unless stimulated to respond

Question 6

B - Cells often need instructions from _____ T Cells to proliferate and differenciate

Answer 6

B - Cells often need instructions from CD4 T Cells to proliferate and differenciate

Question 7

True or False

B - Cell recognition of antigen changes with time

Answer 7

True

Affinitiy and effector functions

Question 8

There are _ classes of Primary Immine Deficiencies

Answer 8

There are 8 classes of Primary Immine Deficiencies

Question 9

Combined immune deficiences refers to…

Answer 9

Combined loss of Humoral and cellular Immunity

Question 10

What is Humoral Immunity?

Answer 10

Liquid immunity = antibody = B Cells

also called antibody deficiencies

E.g Absent B cells

Common variable immune deficiency

HIGM

Question 11

What is Cellular immunity?

Answer 11

Cell - mediated = T Cell

Question 12

Defects in T cells can only be which tyle of Primary Immune deficiency?

Answer 12

Severe Combined Immune Deficiencies

Because CD4 T cells regulate B Cells, so both are affected

Question 13

Every cell in the body contains V(D)J sequences, they noly undergo recombination in …

Answer 13

B - Cells

Question 14

The cutting of the VDJ sequence is triggered by

Answer 14

RAG 1

RAG 2

HMG 1

(enzymes)

Question 15

C regions are _____with a class of immunoglobulin

Answer 15

C regions are idenical with a class of immunoglobulin

Question 16

Whcih part goes first in B cell gene rearrangement?

Answer 16

D and J

Question 17

If a Pro-B cell lacks the RAG/RAX5/syk/BTK or Igaplha-beta genes, will the pro -B cell rpgress to Pre-B Large

Answer 17

No.

only if missing

RAG/RAX5/syk/Lgaplha-beta genes

BTK is needed to mature fro Pre- B large to Pre - B small

Question 18

After Vh gene rearrangement;

The Ig heavy chains pair with the two ______ ____ _____

Answer 18

The Ig heavy chains pair with the two Surrogate Light chains

SLC

Question 19

SLC serves the purpose of a ______ llight chain

Answer 19

generic.

not generated by rearrangement.

Question 20

The LgH - SLC complex pairs with two signalling transduction chains called Iga and IgB form the____-_-__ _____

Answer 20

pre-B-cell receptor

which then sends a success signal into the cell

Question 21

Agammaglobulinaemia is a mutation affecting…

85% affect the ______ ____

Answer 21

human B lymphoctye development

85% affect the X-limked XLA enzyme

Question 22

Why is intravenous immunoglobulin not 1005 effective

Answer 22

no variability, can’t change the effector function