Lecture 1 Flashcards
Blood producing stem cells are called
Haematopoietic stem cells
What type of cell in the Bone Marrow derives all Adaptive Immune cells?
Early Lymphoid Progenitor
Which surface bound immunoglobulin recognises Antigens?
B - Cell antigen receptor
What is Clonal expansion?
The proliferation of stimulated B - Cells
B - Cells are ______ unless stimulated to respond
B - Cells are quiescent unless stimulated to respond
B - Cells often need instructions from _____ T Cells to proliferate and differenciate
B - Cells often need instructions from CD4 T Cells to proliferate and differenciate
True or False
B - Cell recognition of antigen changes with time
True
Affinitiy and effector functions
There are _ classes of Primary Immine Deficiencies
There are 8 classes of Primary Immine Deficiencies
Combined immune deficiences refers to…
Combined loss of Humoral and cellular Immunity
What is Humoral Immunity?
Liquid immunity = antibody = B Cells
also called antibody deficiencies
E.g Absent B cells
Common variable immune deficiency
HIGM
What is Cellular immunity?
Cell - mediated = T Cell
Defects in T cells can only be which tyle of Primary Immune deficiency?
Severe Combined Immune Deficiencies
Because CD4 T cells regulate B Cells, so both are affected
Every cell in the body contains V(D)J sequences, they noly undergo recombination in …
B - Cells
The cutting of the VDJ sequence is triggered by
RAG 1
RAG 2
HMG 1
(enzymes)
C regions are _____with a class of immunoglobulin
C regions are idenical with a class of immunoglobulin
Whcih part goes first in B cell gene rearrangement?
D and J
If a Pro-B cell lacks the RAG/RAX5/syk/BTK or Igaplha-beta genes, will the pro -B cell rpgress to Pre-B Large
No.
only if missing
RAG/RAX5/syk/Lgaplha-beta genes
BTK is needed to mature fro Pre- B large to Pre - B small
After Vh gene rearrangement;
The Ig heavy chains pair with the two ______ ____ _____
The Ig heavy chains pair with the two Surrogate Light chains
SLC
SLC serves the purpose of a ______ llight chain
generic.
not generated by rearrangement.
The LgH - SLC complex pairs with two signalling transduction chains called Iga and IgB form the____-_-__ _____
pre-B-cell receptor
which then sends a success signal into the cell
Agammaglobulinaemia is a mutation affecting…
85% affect the ______ ____
human B lymphoctye development
85% affect the X-limked XLA enzyme
Why is intravenous immunoglobulin not 1005 effective
no variability, can’t change the effector function
