lecture 1-20-16 Flashcards

1
Q
  • copy cellular contents
  • duplicate organelles, DNA, and cytoplasm
  • each new cell has the same amount as original cell
  • called interphase
  • G1,S,G2
A

preparatory phase

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2
Q

cell grows, makes extra cytoplasm

A

G1 Phase

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3
Q

DNA replication occurs, chromosomes

identical sister chromatids

A

S Phase

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4
Q

cell prepares for division

A

G2 phase

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5
Q

three parts of interphase __ ____ and ____

A

G1, S and G2

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6
Q

division phase includes

A

mitosis and cytokinesis

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7
Q

cytokinesis is

A

the division of other organelles

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8
Q
  • chromosomes are evenly divided
  • sister chromatids are separated
  • centromere
A

mitosis

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9
Q
  • enlarged cell splits into two cells
  • each has full complement of DNA
  • one parent cell into two daughter cells
A

cytokinesis

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10
Q

how do cells divide?

A

cytokinesis

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11
Q

occurs in a series of phases;

M Phase

A

Mitosis

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12
Q

phases in order

A

interphase
mitosis and cytokinesis
anaphase
telophase

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13
Q
  • each chromosome is replicated in S phase, resulting in two sister chromatids connected at the centromere
  • chromosomes are loosely gathered in the nucleus
A

interphase

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14
Q
  • replicated chromosomes begin to coil up
  • nuclear membrane begins to disassemble
  • microtubule fibers begin to form the mitotic spindle
A

prophase

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15
Q
  • microtubule spindle fibers from opposite ends of the cell attach to the sister chromatids of each chromosomes
  • replicated chromosomes become aligned along the middle of the cell
A

metaphase

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16
Q

-microtubules shorten pulling the sister chromatids to opposite ends of the cell

A

anaphase

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17
Q
  • identical sets of chromosomes reach each pole
  • microtubule spindle fibers disassemble
  • nuclear membrane forms around each set of chromosomes forming the daughter cell nuclei
18
Q

the structure that separates sister chromatids during mitosis

A

the mitotic spindle

19
Q

hollow protein fibers
key components of cytoskeletons
attach the centromere on chromosome via kinetochore proteins

A

microtubules

20
Q

following mitosis and cytokinesis, daughter cells are __________

A

genetically identical to each other

genetically identical to the parent cell

21
Q

in the cell cycle, DNA is replicated during ______

A

the S phase

22
Q

during ____in animal cells the cell membrane pinches in to separate the daughter cells

A

cytokinesis

23
Q

which of the following processes require normal cell division?

A

all of the above
1. embryonic development
2. wound healing
3.

24
Q

during which stage of the cell cycle do sister chromatids separate from each other ?

25
cytokinesis in plant cells involves the synthesis of a ___________ between the daughter cells
cell wall
26
during which stage of the cell cycle are sister chromatids initially produced
interphase
27
most chemotherapy drugs target cell cycle they _____
interfere with DNA replication, chromosome separation | look to plants as source of drugs
28
the pacific yew is one species of a family of related evergreen trees
taxus brevifolia
29
taxus brevifolia
extract from bark kills cancer cells | taxol
30
- interferes with the normal organization of microtubule - prevents microtubules from shortening - chromatids not separated
taxol
31
- cellular mechanisms - regulate cells progression through cell cycle - ensures each stage is completed accurately
cell cycle checkpoint
32
either repair damage or | direct cell to commit suicide (apoptosis)
cell cycle checkpoints
33
when a normal cell sustains irreparable damage, it undergoes programmed cell death. this cellular suicide prevents cells from producing more damaged daughter cells
apoptosis
34
cells divide uncontrollably
cancer
35
if there's enough DNA damage to interfere with multiple checkpoints
Cancer | tumors
36
__________ divide in an unregulated manner and accumulate DNA damage and make mitotic mistakes
cancer cells
37
cancer kills by:
crowding out normal cells invading other organs secreting poisonous chemicals
38
most effective way to fight cancer?
surgery to remove the cancerous tumor | not effective is the cancer has metastasized
39
high energy radiation beams kills dividing cells damages DNA triggers apoptosis
radiation therapy
40
drugs interfere with cell division
chemotherapy