[LEC] UNIT 3.4 Dynamic Function Test Flashcards
DFT involves stimulating or suppressing a particular _______ ______ and observing the appropriate hormonal
response
hormonal axis
If excess is suspected, conduct a _______
If deficiency is suspected, conduct a ______
suppression test; stimulation test
complete rest for ___ minutes before blood collection is required before test for GH insufficiency
30
Specimen for GH Insufficiency test
Fasting serum
screening test for GH Insufficiency
Exercise test
Confirmatory test for GH Insufficiency
Insulin tolerance test
other name for insulin tolerance test
insulin stress test
insulin stress test is done when this condition is suspected
hypopituitarism
In ITT, insulin is administered to produce hypoglycemic stress of ____ mmol/L
< 2.2
ITT tests the ability of anterior pituitary gland to
produce
ACTH and GH
Expected values of GH and Cortisol in a normal indiv administered with insulin
GH > 6 µg/L
Cortisol > 500 nmol/L
Screening test for acromegaly
Somatomedin C / Insulin-like growth factor 1
Confirmatory test for acromegaly
Glucose suppression test / oral glucose tolerance test (OGTT)
In OGTT, provide ___g of oral glucose
75
Hyperglycemia should suppress the
growth hormone to
< 1 µg/L
T or F: OGTT is also utilized as a confirmatory
test for diabetes mellitus
T
Produced by the liver and to a lesser degree by
skeletal muscles, primarily in response to growth
hormone (GH) stimulation
Somatomedin C
T or F: The blood level of IGF-1 mirrors ACTH levels
F
GH levels
T or F: GH and IGF-1 blood kevels are stable and do not fluctuate throughout the day
F
Only IGF-1 is stable
Deficiencies in IGF-1
lack of responsiveness to GH
Injection of TRH and measurement of the output of TSH
Thyrotropin releasing hormone stimulating test
TRH Stimulating Test is used in the diagnosis of
combined pituitary-thyroid disorders
difference between 2° hypothyroidism and 3° hypothyroidism
Secondary (2°) hypothyroidism: due to pituitary problems
Tertiary (3°) hypothyroidism: due to
hypothalamic disorders
in TRH stimulating test, TRH is given as an
IV bolus
In TRH stimulating test, blood sampling done at
0, 20, 60 minutes
Test to assess hypogonadism
GnRH test
hormone associated with diabetes insipidus
ADH
aka Dehydration Test or Indirect water deprivation test
overnight water deprivation test
T or F: WDT is a concentration test
T
used to distinguish various forms of DI
WDT
