Lec 4 Flashcards
How does mucosa of gastric body differ from that of gastric antrum?
both = lines by tall mucous cell pits
have different gland morphology
What part of stomach has more prominent rugae?
more prominent in corpus than antrum
What is purpose of gastric rugae?
allow for gastric expansion and become flat when stomach filled with food
What is gland morphology of corpus of stomach? What types of cells
long straight tubules with parietal and chief cells, mucous neck cells, enterochromaffin-like [ECL] cells, and D cells
What is gland morphology of antrum?
short coiled mucous glands
some parietal cells, few G cells
What is gland morphology of cardia?
similar to antrum [short coiled glans] but no G cells
What do you see in acute erosive gastritis?
- surface of stomach punctuated by areas of necrosis/erosions
What are some potential complications of acute erosive gastritis?
potential source of GI bleeding
How does erosive gastritis lesion differ from ulcer?
ulcer is a deeper defect –> goes through mucosa into submucosa
What are some etiologies of acute erosive gastritis?
- NSAIDs
- severy physiological stress (stress ulcers) from sepsis, hypoxia, trauma, etc
What causes a curling ulcer?
burn
What causes a cushing ulcer?
trauma or surgery; brain injury
What is acute hemorrhagic gastritis?
acute erosive gastritis w/ necrosis of entire gastric mucosa
What causes chemical gastropathy?
NSAIDS, bile reflux
irritate gastric mucosa and get erosions
What do you see endoscopically/microscopically to distinguish chemical gastropathy?
endoscopically: erythema/redness
microscopically: no inflammation = distinguishes it from gastritis
What are 3 features of chemical gastropathy microscopically?
- loss of epithelial mucin
- dilated capillaries
- corkscrew-shaped gastric pits
What do you see in chronic gastritis?
- mucosa heavily infiltrated by chronic inflammatory cells
What do you see in atrophic gastritis
- atrophy –> thin mucosa, reduced number of glands
- intestinal antral or metaplasia: body glands start to look like antrum or have goblet cells like in intestine
What are the 3 different types of chronic gastritis and their distributions?
type A: autoimmune; body
type B: antral-predominant gastritis
type C: Multifocal atrophic gastritis: pangastritis
What is pathogenesis of type A gastritis?
autoantibodies against parietal cells and/or intrinsic factor
causing loss of parietal cells and B12 deficiency
What findings in type A gastritis?
- B12 deficiency
- achlohydria or hypochlorhydria
- antral G cell hyperplasia
- hypergastrinemia
- ECL cell hyperplasia
High or low acid in autoimmune gastritis?
low acid [hypochlorhydria]