Lec 12 GI Pharm Flashcards
What type of drug: neutralizes acid
antacids
What 2 types of drugs: decreased acid secretion?
- H2 antagonist
- proton pump inhibitor [omeproazole]
What 2 drugs: increase gastric emptying
- metoclopramide
- domperidone
What 3 drugs: increase tone of LES?
- metoclopramide
- cisapride
- bethanechol
What 2 drugs: mucosal protection?
- sucralfate
- alginate
What drug: increased esophageal acid clearance?
metoclopramide
What dysphagia to just solids vs dysphagia to solids + liquids sugest?
just solids = mechanical cause
solids + liquids = motility disorder
What are 4 factors that aid in esophageal acid clearance?
- saliva
- esophageal peristalsis
- gastric emptying
- intact esophageal mucosa
What is action of motilin?
hormone made in duodenum; pro-motility –> increases phase II contractions of MMC
What is an example of a motilin agonist?
erythromycin
What is action of prostaglandins in gastric defense?
- stimulate mucous production
- epithelial cell repair
- bicarbonate
- mucosal blood flow
What is mech of antacids?
local neutralization of acid
Bismuth compound: mech
Bind to ulcer base, providing physical protection and allowing HCO3– secretion to reestablish pH gradient in the mucous layer.
Misoprostol: mech
PGE1 analog.
production and secretion of gastric mucous barrier,acid production.
Misoprostol: toxicity
Diarrhea.
Contraindicated in women of childbearing potential (abortifacient).