Lec 25 Liver Path 2 Flashcards
What is target antigen in primary biliary cirrhosis?
pyruvate dehydrogenase complex on bile duct cells
What do you see grossly in progressed primary biliary cirrhosis?
live looks green
How do you diagnose primary sclerosing cholangitis histologically?
by the onion skin fibrosi and narrowing of bile duct lumen
dilation of preserved segments
What do you see in liver with hereditary hemochromatosis?
brown/bronze liver
very little inflammation
see iron on prussian blue stain
Is wilsons disease assocaited wtih increased risk of hepatocellular carcinoma?
nope!
What stain should you use in wilson disease?
rhodanine stain
What is genetics of alpha 1 antitrypsin deficiency?
autsosomal recessive on chromosome 14
What do you see histologically with alpha 1 antitrypsin deficiency?
round to oval cytoopalsmic globular inclusions in periportal hepatocytes
What stain do youuse for alpha 1 antitrypsin deficiency?
PAS-D stain
What is histology of hepatic adenoma?
- looks like normal hepatocytes
- absent portal tracts, central venules
What is risk factor for hepatic adenoma?
oral contraceptive use
What is a hepatic adenoma?
benign liver tumor
solitary, well demarcated, encapsulated
What is focal nodular hyperplasia?
benign hepatocellular lesion; seen in women in 30s-40s
What are some associated wtih focal nodular hyperplasia?
hemangioma or hepatocellular adenomas
Is FNH malignant?
nope –> can not transform into HCC
What major feature can you use to distinguish focal nodular hyperplasia?
central scar = abnormal vasculature
What is nodular regenerative hyperplasia?
looks like cirrhosis; can cause non-cirrhotic portal hypertension
occurs w/ collagen vascular disease
What are major sources of malignant liver tumors?
- colon
- pancreas
- lung
What do you see on histology in hepatocellular carcinoma?
- heterogeneous
- similar to benign hepatocytes
- no portal tracts
What is pathology of cholagniocarcinoma?
adenocarcinoma with desmoplastic reaction
What are some post transplant complications?
- DM
- hyperlipidemia
- obesity
What is most common cause of death post liver transplant?
cardiovascular related
When do you see acute cellular rejection?
within initial weeks
What are findings of acute cellular rejection?
- high liver enzymes
- CD4 and CD8 cells
- mixed cellular infiltrate
