Lec 18 Liver Flashcards

1
Q

What is the function of hepatocytes?

A

key metabolic cell in liver

most abundant cell

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2
Q

What is function of kupffer cells?

A

liver-specific macrophages

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3
Q

What is the function of hepatic stellate cells in health vs injured liver?

A

in healthy liver: stores vitamin A

becomes activated into myofibroblast-like cell in liver injury = main source of scar in hepatic fibrosis

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4
Q

What is unique about the structure of sinusoidal endothelial cells?

A

they are fenestrated = have pores

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5
Q

What does high AST/ALT suggest?

A

injury to hepatocytes

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6
Q

What are 4 complications of cirrhosis?

A
  • hepatic encephalopathy
  • ascites
  • portal hypertension
  • hepatorenal syndrome
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7
Q

What does high alkaline phosphatase suggest?

A

injury to bile ducts

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8
Q

What are 6 signs of chronic liver disease?

A
  • scleral icterus
  • spider angioma
  • glossitis
  • palmar erythema
  • digital clubbing
  • gynecomastia
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9
Q

What is the most common cause of spider angiomata?

A

pregnancy

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